Evidence map›Paper›PMID 40216811›Full record

ArticleScientific reports2025

A significant correlation exists between CREBBP and CEBPA gene expression in de Novo adult acute myeloid leukemia.

Magda Assem, Asmaa A El Leithy, Naglaa M Hassan, Ahmed A Al-Karmalawy, Mohamed Abozaid, Rasha Mahmoud Allam, Mohamed A M Kamal, Marwa Amer, Gharieb S El-Sayyad, Noha H Ibrahim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Magda Assem *Clinical Pathology Department, National Cancer Institute, Cairo University, Giza, Egypt.
Asmaa A El Leithy *College of Biotechnology, Misr University for Science and Technology, Giza, Egypt. asmaa.elleithy@must.edu.eg.
Naglaa M HassanClinical Pathology Department, National Cancer Institute, Cairo University, Giza, Egypt.
Ahmed A Al-KarmalawyDepartment of Pharmaceutical Chemistry, College of Pharmacy, The University of Mashreq, Baghdad, 10023, Iraq.
Mohamed AbozaidHamilton Lab, School of Medicine, Dentistry and Nursing, Anderson College, University of Glasgow, Glasgow, Scotland, UK.
Rasha Mahmoud AllamDepartment of Cancer Epidemiology and Biostatistics, National Cancer Institute, Cairo University, Giza, Egypt.
Mohamed A M KamalClinical Pathology Department, El-Hussein University Hospital, Al-Azhar University, Cairo, Egypt.
Marwa AmerBioinformatics and Functional Genomics Department, College of Biotechnology, Misr University for Science and Technology (MUST), Giza, Egypt.
Gharieb S El-SayyadMedical Laboratory Technology Department, Faculty of Applied Health Sciences Technology, Badr University in Cairo (BUC), Badr City, Cairo, Egypt. Gharieb.El-Saied@buc.edu.eg.
Noha H IbrahimClinical Pathology Department, National Cancer Institute, Cairo University, Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CREBBP, CEBPA, and DNMT3A are tumor suppressor genes whose dysfunction has been reported in hematologic malignancies. Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. We aim to assess the expression level of CREBBP, CEBPA, and DNMT3A genes in an Egyptian cohort with AML. We investigated the correlation between the selected genes' mRNA levels and their association with clinical characteristics and survival. Herein, 53 adult participants diagnosed with AML were enrolled in the study. Quantitative RT-PCR was used, and computational analysis was added to analyze the relationship between the three genes. CREBBP expression influenced TLC negatively (r = -0.328, p = 0.017). DNMT3A gene expression was found to be significantly associated with CD117 positive (p = 0.028). There was no significant difference between males and females in the relative CREBBP, CEBPA, and DNMT3A expression. Remarkably, AML-M3 cases were devoid of CREBBP expression. The correlation matrix of the three genes detected a significant correlation only between CREBBP and CEBPA expression (r = 0.518, p < 0.0001), though the computational correlation analysis of these two genes was not significant. Our finding may suggest a complementary role of CREBBP and CEBPA in AML pathogenesis; however, further investigation on larger samples is still warranted to study the relationship of these genes with AML survival. We are also reporting here an adult AML case with an additional chromosome 19 as the sole cytogenetic abnormality.

Indexed as

CCAAT-Enhancer-Binding ProteinsCREB-Binding ProteinGene Expression Regulation, LeukemicLeukemia, Myeloid, AcuteAdolescentAdultAgedDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AFemaleHumansMaleMiddle AgedYoung AdultCCAAT-Enhancer-Binding ProteinsCEBPA protein, humanCREB-Binding ProteinCREBBP protein, humanDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanAcute myeloid leukemiaCEBPACREBBPDNMT3ART-PCR

Identifiers

PMID40216811
PMCPMC11992167

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.