ArticleTranslational psychiatry2025
Genetic modulation of brain dynamics in neurodevelopmental disorders: the impact of copy number variations on resting-state EEG.
Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Machine Learning Algorithms in EEG Analysis of Kleefstra Syndrome: Current Evidence and Future Directions.Sensors (Basel, Switzerland) · 2025Review
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10 authors.
Funding
Abstract
Research has shown that many copy number variations (CNVs) increase the risk of neurodevelopmental disorders (e.g., autism, ADHD, schizophrenia). However, little is known about the effects of CNVs on brain development and function. Resting-state electroencephalography (EEG) is a suitable method to study the disturbances of neuronal functioning in CNVs. We aimed to determine whether there are resting-state EEG signatures that are characteristic of children with pathogenic CNVs. EEG resting-state brain activity of 109 CNV carriers (66 deletion carriers, 43 duplication carriers) aged 3 to 17 years was recorded for 4 minutes. To better account for developmental variations, EEG indices (power spectral density and functional connectivity) were corrected with a normative model estimated from 256 Healthy Brain Network controls. Results showed a decreased exponent of the aperiodic activity and a reduced alpha peak frequency in CNV carriers. Additionally, the study showed altered periodic components and connectivity in several frequency bands. Deletion and duplication carriers exhibited a similar overall pattern of deviations in spectral and connectivity measures, although the significance and effect sizes relative to the control group varied across frequency bands. Deletion and duplication carriers can be differentiated by their periodic power in the gamma band and connectivity in the low alpha band, with duplication carriers showing more disrupted alterations than deletion carriers. The distinctive alterations in spectral patterns were found to be most prominent during adolescence. The results suggest that CNV carriers show electrophysiological alterations compared to neurotypical controls, regardless of the gene dosage effect and their affected genomic region. At the same time, while duplications and deletions share common electrophysiological alterations, each exhibits distinct brain alteration signatures that reflect gene dosage-specific effects.
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