ArticleNature communications2025
Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele.
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In one paragraph
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed.
- Shared and distinct genetic architectures of eating disorders and obesity: From monogenic causes to polygenic risk.Reviews in endocrine & metabolic disorders · 2026Review
- Genetic variability in the leptin-melanocortin pathway and its role in weight loss.Molecular metabolism · 2026Review
- Bridging population and cell: modelling complex diseases with human induced pluripotent stem cells.European journal of human genetics : EJHG · 2026Review
- Rare coding and noncoding variants map 1,342 diseases and biomarkers in 490,549 whole genomes.medRxiv : the preprint server for health sciences · 2026Article
- Exploring and visualizing stratified GWAS results with PheWeb2.Nature genetics · 2026Article
- Genetics of Thyroid Function: Relevance for Biology and Disease Management.The Journal of clinical endocrinology and metabolism · 2025Review
- Genome-Wide Association Study for Weight-Related Traits inAnimals : an open access journal from MDPI · 2025Article
- Genomic privacy and security in the era of artificial intelligence and quantum computing.Discover computing · 2025Review
Corrections and comments
- Update of
Authors and funding
125 authors.
Xinruo Zhang *Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. xinruo@email.unc.edu.ORCID http://orcid.org/0000-0001-5789-4592
Jennifer A Brody *Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8509-148X
Mariaelisa Graff *Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-6380-1735
Heather M Highland *Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-3583-8239
Nathalie Chami *The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8547-6424
Hanfei XuDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
Zhe WangThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8046-4969
Kendra R FerrierDivision of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-8813-6871
Geetha ChittoorPopulation Health Sciences, Geisinger, Danville, PA, USA.
Navya Shilpa JosyulaPopulation Health Sciences, Geisinger, Danville, PA, USA.ORCID http://orcid.org/0000-0003-2782-8812
Mariah MeyerDivision of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-9635-5196
Shreyash GuptaPopulation Health Sciences, Geisinger, Danville, PA, USA.
Xihao LiDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8151-0106
Zilin LiBiostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA.
Matthew A AllisonDepartment of Family Medicine, Division of Preventive Medicine, The University of California San Diego, La Jolla, CA, USA.
Diane M BeckerDepartment of Medicine, General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3443-8030
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3409-1110
Meher Preethi BoorgulaDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Donald W BowdenDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jai G BroomeDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7638-0749
Erin J ButhDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Christopher S CarlsonDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Kyong-Mi ChangThe Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-6811-9364
Sameer ChavanDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-0220-0845
Yen-Feng ChiuInstitute of Population Health Sciences, National Health Research Institutes, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-3352-4500
Lee-Ming ChuangDepartment of Internal Medicine, Division of Metabolism/Endocrinology, National Taiwan University Hospital, Taipei, Taiwan.ORCID http://orcid.org/0000-0003-0978-2662
Matthew P ConomosDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9744-0851
Dawn L DeMeoDepartment of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Mengmeng DuDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ravindranath DuggiralaLife Sciences, College of Arts and Sciences, Texas A&M University-San Antonio, San Antonio, TX, USA.
Celeste EngDepartment of Medicine, Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.
Alison E FohnerEpidemiology, Institute of Public Health Genetics, School of Public Health, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-4231-3331
Barry I FreedmanInternal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0003-0275-5530
Melanie E GarrettDuke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0003-2302-6150
Xiuqing GuoDepartment of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0002-5264-5068
Chris HaimanPreventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Benjamin D HeavnerDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2898-9044
Bertha HidalgoDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-2556-1969
James E HixsonDepartment of Epidemiology, School of Public Health, UTHealth Houston, Houston, TX, USA.
Yuk-Lam HoVeterans Affairs Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3305-3830
Brian D HobbsDepartment of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Donglei HuDepartment of Medicine, Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-0351-001X
Qin HuiDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Chii-Min HwuDepartment of Medicine, Division of Endocrinology and Metabolism, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan.ORCID http://orcid.org/0000-0002-8209-9627
Rebecca D JacksonEndocrinology, Ohio State University, Columbus, OH, USA.
Deepti JainDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Rita R KalyaniDepartment of Medicine, Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Tanika N KellyDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Ethan M LangeDivision of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.
Michael LeNoirDepartment of Pediatrics, Bay Area Pediatrics, Oakland, CA, USA.
Changwei LiDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.ORCID http://orcid.org/0000-0002-9203-304X
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Merry-Lynn N McDonaldDepartment of Medicine, Pulmonary, Allergy and Critical Care, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-2647-9422
Caitlin P McHughDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Alanna C MorrisonDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0001-6381-4296
Take NaseriNaseri & Associates Public Health Consultancy Firm and Family Health Clinic, Apia, Samoa.
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Jeffrey O'ConnellDepartment of Medicine, Program for Personalized and Genomic Medicine, University of Maryland, Baltimore, MD, USA.
Christopher J O'DonnellVeterans Affairs Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2667-8624
Nicholette D PalmerDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0001-8883-2511
James S PankowDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-7076-483X
James A PerryDepartment of Medicine, School of Medicine, University of Maryland, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-5050-2074
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5666-9318
Michael H PreussThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5266-8465
D C RaoCenter for Biostatistics and Data Science, Washington University in St. Louis, St. Louis, MO, USA.
Elizabeth A ReganDepartment of Medicine, Rheumatology, National Jewish Health, Denver, CO, USA.
Sefuiva M ReupenaLutia i Puava ae Mapu i Fagalele, Apia, Samoa.
Dan M RodenMedicine, Pharmacology, and Biomedical Informatics, Clinical Pharmacology and Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-6302-0389
Jose Rodriguez-SantanaCentro de Neumologia Pediatrica, San Juan, PR, USA.
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3575-5468
Hemant K TiwariDepartment of Biostatistics, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA.
Ramachandran S VasanDepartment of Medicine, School of Medicine, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7357-5970
Zeyuan WangDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Daniel E WeeksDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-9410-7228
Jennifer WesselDepartment of Epidemiology, Indiana University, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-7031-0085
Kerri L WigginsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2749-1279
Lynne R WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Peter W F WilsonAtlanta VA Health Care System, Decatur, GA, USA.
Lisa R YanekDepartment of Medicine, General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-7117-1075
Zachary T YonedaDepartment of Medicine, Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7388-0692
Sebastian ZöllnerDepartment of Biostatistics, Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7362-156X
Donna K ArnettDepartment of Epidemiology, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Allison E Ashley-KochDuke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0001-5409-9155
Kathleen C BarnesDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-3030-4705
John BlangeroDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, USA.ORCID http://orcid.org/0000-0001-6250-5723
Eric BoerwinkleDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Esteban G BurchardBioengineering and Therapeutic Sciences and Medicine, Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7475-2035
April P CarsonDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.ORCID http://orcid.org/0000-0002-7970-6756
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3357-0862
Yii-Der Ida ChenDepartment of Medical Genetics, Genomic Outcomes, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0003-1741-3517
Joanne E CurranDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, USA.ORCID http://orcid.org/0000-0002-6898-155X
Myriam FornageDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0677-8158
Victor R GordeukDepartment of Medicine, School of Medicine, University of Illinois at Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4725-7295
Jiang HeDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.ORCID http://orcid.org/0000-0002-8286-9652
Susan R HeckbertCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7100-512X
Lifang HouNorthwestern University, Chicago, IL, USA.
Marguerite R IrvinDepartment of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7986-8560
Ryan L MinsterDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-7382-6717
Braxton D MitchellDepartment of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-4920-4744
Mehdi NouraieDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7278-2190
Laura M RaffieldDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-1427-4470
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-3872-7793
Jerome I RotterDepartment of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0001-7191-1723
M Benjamin ShoemakerDepartment of Medicine, Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Nicholas L SmithDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3483-353X
Kent D TaylorDepartment of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Marilyn J TelenDepartment of Medicine, Division of Hematology, Duke University School of Medical, Durham, NC, USA.ORCID http://orcid.org/0000-0003-3809-1780
Scott T WeissDepartment of Medicine, Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7196-303X
Yingze ZhangDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-6947-2901
Nancy Heard-CostaFramingham Heart Study, School of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9730-0306
Yan V SunDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-2838-1824
Xihong LinDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7067-7752
L Adrienne CupplesDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0273-7965
Leslie A LangeDivision of Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.
Ching-Ti LiuDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0703-0742
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8532-5087
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-8903-0366
Anne E JusticePopulation Health Sciences, Geisinger, Danville, PA, USA. aejustice1@geisinger.edu.ORCID http://orcid.org/0000-0002-8903-8712
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MGenetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MWORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WASHBURN, LISA K · 1992 to 2010
$35.2MTulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Katherine Teresa Mills · 2016 to 2026
$25.3MTranslating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher I. Amos, Rayjean J. Hung · 2017 to 2026
$23.7MNew Approaches for Empowering Studies of Asthma in Populations of African DescentR01HL104608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, KENNY, EIMEAR ELIZABETH · 2011 to 2022
$23.1MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7MHYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHYR01HL055673 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 1996 to 2016
$18.1MCell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1MSystems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2016 to 2020
$12.6MGenetic and Environmental Determinants of TriglyceridesU01HL072524 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 2002 to 2008
$11.9MNorth Carolina Translational and Clinical Science Institute (NC TraCS) KL2KL2TR002490 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEINBERGER, MORRIS · 2018 to 2022
$11.0MBLRD VA I01 BX003340BLRD VA I01 BX003362BLRD VA I01 BX004821NCATS NIH HHS KL2 TR002490NCI NIH HHS P01 CA134294NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA197449NCI NIH HHS U19 CA203654NCRR NIH HHS M01 RR007122NHGRI NIH HHS R01 HG010297NHGRI NIH HHS U01 HG007416NHGRI NIH HHS U01 HG009088NHLBI NIH HHS F32 HL085989NHLBI NIH HHS K08 HL136928NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL055673NHLBI NIH HHS R01 HL067348NHLBI NIH HHS R01 HL068959NHLBI NIH HHS R01 HL092301NHLBI NIH HHS R01 HL093093NHLBI NIH HHS R01 HL104135NHLBI NIH HHS R01 HL104608NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL113338NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL133040NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R01 HL142825NHLBI NIH HHS R01 HL153460NHLBI NIH HHS R01 HL163262NHLBI NIH HHS R01 HL163560NHLBI NIH HHS R01 HL172803NHLBI NIH HHS R01 HL173044NHLBI NIH HHS T32 HL007055NHLBI NIH HHS T32 HL129982NHLBI NIH HHS U01 HL054472NHLBI NIH HHS U01 HL054473NHLBI NIH HHS U01 HL054495NHLBI NIH HHS U01 HL054509NHLBI NIH HHS U01 HL072507NHLBI NIH HHS U01 HL072524NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL120393NIAID NIH HHS R01 AI114555NIAID NIH HHS R01 AI132476NIAMS NIH HHS R01 AR048797NIA NIH HHS R01 AG058921NIBIB NIH HHS R01 EB015611NIDDK NIH HHS R01 DK071891NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK107786NIDDK NIH HHS R01 DK110113NIDDK NIH HHS R01 DK122503NIDDK NIH HHS R01 DK124097NIDDK NIH HHS R01 DK135938NIGMS NIH HHS P20 GM109036NINDS NIH HHS R01 NS058700U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) R01 DK 122503
Abstract
Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European individuals. This study leveraged whole-genome sequencing (WGS) data from 88,873 participants from the Trans-Omics for Precision Medicine (TOPMed) Program, of which 51% were of non-European population groups. We discovered 18 BMI-associated signals (P < 5 × 10
Indexed as
African PeopleBody Mass IndexObesityWhole Genome SequencingAdultAllelesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotidePopulation Groups
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