ArticleNature communications2025
Small molecule BLVRB redox inhibitor promotes megakaryocytopoiesis and stress thrombopoiesis in vivo.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Assessing the ligand native-like pose using a quantum mechanical-derived hydropathic score for protein-ligand complementarity.npj drug discovery · 2026Article
- Scalable bioreactor manufacturing of iPSC-derived megakaryocytes with Proanthocyanidin A supplementation: a strategic platform for military blood supply resilience.Military Medical Research · 2026Article
- Biliverdin reductase B as a new target in breast cancer.Breast cancer research : BCR · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Biliverdin IXβ reductase (BLVRB) is an NADPH-dependent enzyme previously implicated in a redox-regulated mechanism of thrombopoiesis distinct from the thrombopoietin (TPO)/c-MPL axis. Here, we apply computational modeling to inform molecule design, followed by de novo syntheses and screening of unique small molecules retaining the capacity for selective BLVRB inhibition as a novel platelet-enhancing strategy. Two distinct classes of molecules are identified, and NMR spectroscopy and co-crystallization studies confirm binding modes within the BLVRB active site and ring stacking between the nicotinamide moiety of the NADP
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