ArticleDoklady. Biochemistry and biophysics2025
Quantitative Assessment of T-Regulatory Cell Population and FOXP3 Gene Expression in Chronically Exposed Residents of the Urals Region.
Article in Doklady. Biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective is to conduct a pilot study on the quantity of regulatory T-cells (Treg) in the peripheral blood and to assess transcriptional activity of FOXP3 gene in chronically exposed persons. Materials and methods. The study included 77 participants who were divided into two groups: exposed people-45 individuals, with a mean cumulative dose to red bone marrow (RBM) of 641.21 ± 80.41 mGy, and a comparison group-32 individuals, with a mean cumulative RBM dose of 20.38 ± 2.51 mGy. The study on the assessment of the FOXP3 gene expression was conducted in 298 individuals: the exposed group consisted of 163 individuals with a mean cumulative dose to RBM of 702 ± 43.10 mGy; the comparison group included 135 individuals with a mean cumulative dose to RBM of 17.30 ± 1.40 mGy. The study groups did not differ significantly in age, sex, and ethnicity. Quantitative assessment of regulatory T-cells in the peripheral blood was performed using flow cytometry method by the presence of T-helper markers CD3 and CD4, high expression of marker CD25 and low expression of marker CD127. Thus, the phenotype of regulatory T-lymphocytes was described as CD3+CD4+CD25highCD127low. The relative mRNA content of the FOXP3 gene was assessed by PCR-RT. Results. More than 70 years after the onset of chronic exposure, no statistically significant changes in the pool of regulatory T-cells were detected in the exposed persons: the content of absolute and relative number of Treg did not differ statistically significantly between the studied groups (p = 0.91 and p = 0.29, respectively); no statistically significant relationship between Treg indices and the cumulative doses to RBM and thymus and peripheral lymphoid organs were found. No statistically significant differences in FOXP3 gene mRNA expression were found between exposed individuals and the comparison group. A linear positive dependence of FOXP3 gene mRNA expression on the relative number of regulatory T-cells was shown (p = 0.007).
Indexed as
Identifiers
40216726What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.