Evidence map›Paper›PMID 40216693›Full record

ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2025

Exploring the molecular mechanisms of multiple antifungal drug-resistant genes expression in Candida tropicalis: an emerging threat in vulvovaginal candidiasis patients.

Umber Tasneem, Baharullah Khattak, Fozia Fozia, Noor Akbar, Shangrong Fan, Iqbal Nisa, Taj Ali Khan, Rani Faryal, Ijaz Ahmad, Mohamed Mohany and 2 more

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Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Umber TasneemDepartment of Microbiology, Kohat University of Science and Technology, Kohat, 26000, Khyber Pakhtunkhwa, Pakistan.
Baharullah KhattakDepartment of Microbiology, Kohat University of Science and Technology, Kohat, 26000, Khyber Pakhtunkhwa, Pakistan. dr.baharullah@kust.edu.pk.
Fozia FoziaDepartment of Biochemistry, KMU Institute of Medical Sciences, Kohat, 26000, Pakistan. drfoziazeb@yahoo.com.
Noor AkbarDepartment of Zoology, Kohat University of Science and Technology, Kohat, Pakistan.
Shangrong FanDepartment of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Iqbal NisaDepartment of Microbiology, Women University Swabi, Swabi, Pakistan.
Taj Ali KhanDepartment of Medicine, University of Florida, Gainesville, USA.
Rani FaryalDepartment of Microbiology, Azam University Islamabad, Islamabad, 45320, Quaide, Pakistan.
Ijaz AhmadDepartment of Chemistry, Kohat University of Science and Technology, Kohat, 26000, Khyber Pakhtunkhwa, Pakistan.
Mohamed MohanyDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 55760, 11451, Riyadh, Saudi Arabia.
Salim S Al-RejaieDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 55760, 11451, Riyadh, Saudi Arabia.
Sinisa DjurasevicFaculty of Biology, University of Belgrade, Studentski Trg 16, 11158, Belgrade118, Serbia.

Funding

Khyber Medical University Publication Fund (No.DIR/ORIC/Ref/24/00070).King Saud University Researchers Supporting Project (RSPD2025R758)
6 · The paper itself

Abstract

Vulvovaginal Candidiasis (VVC) is increasingly caused by non-Candida albicans species due to antifungal drug misuse. Resistance to Candida tropicalis is particularly concerning, as persistent infections are linked to resistant isolates. This study investigated the expression of eight drug-resistant genes in 39 C. tropicalis strains from China and Pakistan. RT-qPCR analysis revealed ERG 1 as the most highly upregulated gene, while CDR2 was the most downregulated. Notably, ERG 1 was the most upregulated gene in Pakistani strains, while ERG 6 was most upregulated in Chinese strains. Our findings highlight the overexpression of ERG1, ERG11, CDR1, CDR2, and MDR1, providing insights into the molecular mechanisms of antifungal resistance. This study has significant clinical implications for improving patient outcomes in the face of rising resistant infections.

Indexed as

Antifungal AgentsCandida tropicalisCandidiasis, VulvovaginalDrug Resistance, FungalDrug Resistance, Multiple, FungalChinaFemaleFungal ProteinsGene Expression Regulation, FungalHumansMicrobial Sensitivity TestsPakistanAntifungal AgentsFungal ProteinsCandida tropicalisDrug resistanceDrug-resistant genesRT-qPCR

Identifiers

PMID40216693

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.