Evidence map›Paper›PMID 40216681›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2025

Regenerative Potential of Platelet-Rich Plasma in Diabetes Mellitus.

T I Vlasova, E P Brodovskaya, K S Madonov, V P Ageev, A P Abelova, S I Pinyaev, A P Vlasov

Abstract read
PubMed Publisher
In one paragraph

Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

T I VlasovaOgarev National Research Mordovian State University, Saransk, Russia. v.t.i@bk.ru.
E P BrodovskayaOgarev National Research Mordovian State University, Saransk, Russia.
K S MadonovOgarev National Research Mordovian State University, Saransk, Russia.
V P AgeevOgarev National Research Mordovian State University, Saransk, Russia.
A P AbelovaOgarev National Research Mordovian State University, Saransk, Russia.
S I PinyaevOgarev National Research Mordovian State University, Saransk, Russia.
A P VlasovOgarev National Research Mordovian State University, Saransk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The regenerative potential of platelet-rich plasma (PRP) samples from patients with type 1 diabetes mellitus (DM) was studied in vitro. In a series of experiments, PRP was added to the culture medium of human dermal fibroblasts. The cells were tested for metabolic (including reactive oxygen species production), migration, and proliferative activities at several time points; growth factors and exosome levels were assessed in PRP and the medium. A lower proliferative effect, pro-oxidant properties, and toxicity were observed for PRPs from diabetic patients. Namely, treated fibroblasts showed lower metabolic activity, a lower cell viability, and a greater percentage of necrosis in culture, while their migration properties were not impaired. PRPs from diabetic patients exerted a lower stimulatory effect on growth factor secretion by dermal fibroblasts. PRPs from elderly diabetics had the greatest effects.

Indexed as

Diabetes Mellitus, Type 1FibroblastsPlatelet-Rich PlasmaRegenerationAdultAgedCell MovementCell ProliferationCells, CulturedFemaleHumansMaleMiddle AgedReactive Oxygen SpeciesReactive Oxygen Speciesdiabetes mellituspersonalized medicineplatelet-rich plasmaPRP therapyregenerative medicine

Identifiers

PMID40216681

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.