Evidence map›Paper›PMID 40216676›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2025

Ontogeny of the Epileptic System in the Krushinsky-Molodkina Rat Strain with Genetically Determined Audiogenic Epilepsy.

S A Litvinova, A A Yakovleva, T A Voronina, N A Gladysheva, V V Radontseva, N M Surina, I I Poletaeva, I B Fedotova, A D Durnev

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Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

S A LitvinovaFederal Research Center for Innovative and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia. litvinova_sa@academpharm.ru.
A A YakovlevaFederal Research Center for Innovative and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia.
T A VoroninaFederal Research Center for Innovative and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia.
N A GladyshevaFederal Research Center for Innovative and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia.
V V RadontsevaFederal Research Center for Innovative and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia.
N M SurinaBiological Faculty, Moscow State University, Moscow, Russia.
I I PoletaevaBiological Faculty, Moscow State University, Moscow, Russia.
I B FedotovaBiological Faculty, Moscow State University, Moscow, Russia.
A D DurnevFederal Research Center for Innovative and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Susceptibility to audiogenic epilepsy (AE) seizures and phenotypic manifestations of epileptic activity in rats of the Krushinsky-Molodkina (KM) strain were shown to develop in parallel with the appearance of seizure EEG patterns from 2 to 7 months of age. The seizure latency decreased with age, while the intensity of convulsive seizures increased. Two types of epileptiform discharges (EDs) were identified in background EEGs (no exposure to sound) of KM rats. One type had a form of high-amplitude generalized packs of waves with the animal shuddering. The other type had a form of generalized non-seizure absence-like spike-and-wave discharges with the animal freezing. The total and mean durations of single absence-like discharges increased with age. Parallel age-related increases in the severity of AE seizures and the number of generalized absence-like discharges in the forebrain EEG suggests the development of the epileptic system in KM rats.

Indexed as

Epilepsy, ReflexAnimalsDisease Models, AnimalElectroencephalographyMaleRatsSeizuresaudiogenic epilepsyEEG epileptiform dischargeepileptic systemKrushinsky–Molodkina rat strainseizuresspike-and-wave

Identifiers

PMID40216676

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.