Trial reportRegional anesthesia and pain medicine2026
Ultrasound guidance does not improve local anesthetic distribution in suprazygomatic maxillary nerve blocks in pediatric patients: a clinical, randomized, controlled, observer-blinded, crossover MRI trial.
Trial report in Regional anesthesia and pain medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05778903 (Maxillary Nerve Blocks in Children - An MRI Study of the Suprazygomatic), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Maxillary Nerve Blocks in Children - An MRI Study of the Suprazygomatic
Who cites it
1 citing paper in PubMed.
- Simulation of suprazygomatic and infrazygomatic approaches for maxillary nerve block in children.Journal of anesthesia · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMaxillary nerve blocks are often used as part of a multimodal postoperative pain management regimen for children undergoing cleft palate surgery. It has not been demonstrated yet that ultrasound guidance provides superior local anesthetic distribution and better success rates compared with the landmark-based block technique. The aim of the study was to compare the effect of ultrasound guidance for suprazygomatic maxillary nerve blocks on local anesthetic spread to the pterygopalatine fossa.
methods20 pediatric patients scheduled for cleft palate repair received bilateral suprazygomatic maxillary blocks. Landmark technique was used on one side and ultrasound guidance on the contralateral side according to randomization. After the block procedure, MRI was used to determine the spread of the local anesthetic.
resultsLocal anesthetic spread to the pterygopalatine fossa with contact to the maxillary nerve (defined as successful block) was observed in 13 (65%) of the landmark-based blocks and in 14 (70%) of the ultrasound-guided blocks (p=0.56). No adverse events or complications were observed during or after the block procedures.
conclusionAppropriate pain management for cleft palate repair can be achieved without the availability of imaging guidance. Future studies should focus on improving the success rate of maxillary nerve blocks, both with and without the aid of sonography. TRIAL REGISTRATION NUMBER: NCT05778903.
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