Evidence map›Paper›PMID 40216437›Full record

Trial reportCanadian journal of surgery. Journal canadien de chirurgie

Fast Track Pathway to Accelerated Cholecystectomy Versus Standard of Care for Acute Cholecystitis (FAST) pilot trial.

Flavia K Borges, Rahima Nenshi, Pablo E Serrano, Paul Engels, Kelly Vogt, Lily J Park, Emily Di Sante, Jessica Vincent, Kate Tsiplova, P J Devereaux

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Canadian journal of surgery. Journal canadien de chirurgie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04033822 (Fast Track Pathway to Accelerated Cholecystectomy Versus Standard of Care for Acute Cholecystitis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04033822 naactive not recruitingnot on this map

Fast Track Pathway to Accelerated Cholecystectomy Versus Standard of Care for Acute Cholecystitis

TypeinterventionalSponsorP.J. DevereauxRan2020 to 2025Enrolled60ConditionsCholecystitis, CholecystectomyArmscholecystectomy
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Flavia K BorgesFrom the Population Health Research Institute, Hamilton, Ont. (Borges, Nenshi, Park, Di Sante, Vincent, Tsiplova, Devereaux); the Department of Medicine, McMaster University, Hamilton, Ont. (Borges, Devereaux); the Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ont. (Borges, Park, Devereaux); the Department of Surgery, Division of General Surgery, McMaster University, Hamilton, Ont. (Nenshi, Serrano, Engels, Park); the Department of Surgery, Division of General Surgery, Western University, London, Ont. (Vogt) flavia.borges@phri.ca.
Rahima NenshiFrom the Population Health Research Institute, Hamilton, Ont. (Borges, Nenshi, Park, Di Sante, Vincent, Tsiplova, Devereaux); the Department of Medicine, McMaster University, Hamilton, Ont. (Borges, Devereaux); the Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ont. (Borges, Park, Devereaux); the Department of Surgery, Division of General Surgery, McMaster University, Hamilton, Ont. (Nenshi, Serrano, Engels, Park); the Department of Surgery, Division of General Surgery, Western University, London, Ont. (Vogt).
Pablo E SerranoFrom the Population Health Research Institute, Hamilton, Ont. (Borges, Nenshi, Park, Di Sante, Vincent, Tsiplova, Devereaux); the Department of Medicine, McMaster University, Hamilton, Ont. (Borges, Devereaux); the Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ont. (Borges, Park, Devereaux); the Department of Surgery, Division of General Surgery, McMaster University, Hamilton, Ont. (Nenshi, Serrano, Engels, Park); the Department of Surgery, Division of General Surgery, Western University, London, Ont. (Vogt).
Paul EngelsFrom the Population Health Research Institute, Hamilton, Ont. (Borges, Nenshi, Park, Di Sante, Vincent, Tsiplova, Devereaux); the Department of Medicine, McMaster University, Hamilton, Ont. (Borges, Devereaux); the Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ont. (Borges, Park, Devereaux); the Department of Surgery, Division of General Surgery, McMaster University, Hamilton, Ont. (Nenshi, Serrano, Engels, Park); the Department of Surgery, Division of General Surgery, Western University, London, Ont. (Vogt).
Kelly VogtFrom the Population Health Research Institute, Hamilton, Ont. (Borges, Nenshi, Park, Di Sante, Vincent, Tsiplova, Devereaux); the Department of Medicine, McMaster University, Hamilton, Ont. (Borges, Devereaux); the Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ont. (Borges, Park, Devereaux); the Department of Surgery, Division of General Surgery, McMaster University, Hamilton, Ont. (Nenshi, Serrano, Engels, Park); the Department of Surgery, Division of General Surgery, Western University, London, Ont. (Vogt).
Lily J ParkFrom the Population Health Research Institute, Hamilton, Ont. (Borges, Nenshi, Park, Di Sante, Vincent, Tsiplova, Devereaux); the Department of Medicine, McMaster University, Hamilton, Ont. (Borges, Devereaux); the Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ont. (Borges, Park, Devereaux); the Department of Surgery, Division of General Surgery, McMaster University, Hamilton, Ont. (Nenshi, Serrano, Engels, Park); the Department of Surgery, Division of General Surgery, Western University, London, Ont. (Vogt).
Emily Di SanteFrom the Population Health Research Institute, Hamilton, Ont. (Borges, Nenshi, Park, Di Sante, Vincent, Tsiplova, Devereaux); the Department of Medicine, McMaster University, Hamilton, Ont. (Borges, Devereaux); the Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ont. (Borges, Park, Devereaux); the Department of Surgery, Division of General Surgery, McMaster University, Hamilton, Ont. (Nenshi, Serrano, Engels, Park); the Department of Surgery, Division of General Surgery, Western University, London, Ont. (Vogt).
Jessica VincentFrom the Population Health Research Institute, Hamilton, Ont. (Borges, Nenshi, Park, Di Sante, Vincent, Tsiplova, Devereaux); the Department of Medicine, McMaster University, Hamilton, Ont. (Borges, Devereaux); the Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ont. (Borges, Park, Devereaux); the Department of Surgery, Division of General Surgery, McMaster University, Hamilton, Ont. (Nenshi, Serrano, Engels, Park); the Department of Surgery, Division of General Surgery, Western University, London, Ont. (Vogt).
Kate TsiplovaFrom the Population Health Research Institute, Hamilton, Ont. (Borges, Nenshi, Park, Di Sante, Vincent, Tsiplova, Devereaux); the Department of Medicine, McMaster University, Hamilton, Ont. (Borges, Devereaux); the Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ont. (Borges, Park, Devereaux); the Department of Surgery, Division of General Surgery, McMaster University, Hamilton, Ont. (Nenshi, Serrano, Engels, Park); the Department of Surgery, Division of General Surgery, Western University, London, Ont. (Vogt).
P J DevereauxFrom the Population Health Research Institute, Hamilton, Ont. (Borges, Nenshi, Park, Di Sante, Vincent, Tsiplova, Devereaux); the Department of Medicine, McMaster University, Hamilton, Ont. (Borges, Devereaux); the Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ont. (Borges, Park, Devereaux); the Department of Surgery, Division of General Surgery, McMaster University, Hamilton, Ont. (Nenshi, Serrano, Engels, Park); the Department of Surgery, Division of General Surgery, Western University, London, Ont. (Vogt).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTiming to surgery for acute cholecystitis remains variable, ranging from early (< 7 d) to delayed surgery (> 7 d). Accelerated surgery may result in better outcomes owing to reduced exposure to hypercoagulable and inflammatory states. We sought to determine the feasibility of a trial comparing accelerated surgery with standard care among patients with calculous acute cholecystitis.

methodsWe conducted a multicentre pilot randomized controlled trial. We randomly assigned adult patients with acute cholecystitis to receive accelerated surgery (i.e., goal of surgery within 6 hours of diagnosis) or standard care. The primary feasibility outcome included recruitment of 60 patients, randomly assigning the equivalent of 1 patient per site per month, and 95% follow-up at 90 days.

resultsSixty patients (mean age 61.7, standard deviation [SD] 13.5, yr; 27 [45%] female) were randomly assigned to accelerated surgery (

conclusionIn our pilot trial, we found that accelerated cholecystectomy was achievable. These results show the feasibility of a trial comparing accelerated and standard care among patients requiring surgery for acute cholecystitis and support a definitive trial.

trial registrationClinicalTrials.gov, no. NCT04033822.

Indexed as

CholecystectomyCholecystitis, AcuteStandard of CareTime-to-TreatmentAdultAgedFeasibility StudiesFemaleHumansMaleMiddle AgedPilot Projects

Identifiers

PMID40216437
PMCPMC11999720

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.