Trial reportBrain, behavior, and immunity2025
Factors associated with inflammatory cytokines in family caregivers of allogeneic hematopoietic stem cell transplantation (HSCT) recipients.
Trial report in Brain, behavior, and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Exploratory Analysis of Inflammatory Biomarkers and Their Association with Psychological Burden in Mexican Informal Caregivers: A Cross-Sectional Study in the Emergency Department.International journal of molecular sciences · 2026Article
- INTERLEUKIN-6 AND INTERLEUKIN-10 AS BIOMARKERS OF HEPATOCELLULAR CARCINOMA PROGRESSION: A CROSS-SECTIONAL ANALYSIS OF NUTRITIONAL, CYTOKINE AND SURVIVAL PARAMETERS.Arquivos de gastroenterologia · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundFamily caregiving has been proposed as chronic stress that may lead to immune health risks through increased systemic inflammation. Cytokines are key modulators of inflammation via a complex network of interactions. However, most studies examined only a single to a few cytokines to determine whether they correlate with psychobehavioral variables of interest. This study aimed to investigate factors influencing multiple inflammatory cytokines in family caregivers of allogeneic hematopoietic stem cell transplantation (HSCT) recipients.
methodsBaseline data from a randomized controlled clinical trial at the National Institutes of Health Clinical Center were collected from caregivers of allogeneic HSCT recipients. The 20 serum cytokine levels were measured using multiplexed cytokine immunoassays. Multiple linear regression was conducted.
resultsCaregivers (N = 45) were 44.6 ± 15.4 years of age; primarily female (87 %), White (66 %), non-Hispanic (82 %), and a spouse/partner of the HSCT recipient (56 %). Caring for HSCT recipients with hematologic malignancy predicted higher IL-12/IL-23p40 than caring for non-malignant HSCT recipients (β = 0.291, p = 0.044). Medication use was associated with higher IL-15 (β = 0.425, p = 0.017). Caregiver BMI overweight (β = 0.342, p = 0.043) or obese (β = 0.411, p = 0.010), taking prescribed medications (β = 0.521, p = 0.007), caregiving 8 to 16 h (β = 0.396, p = 0.027) or more than 16 h per day (β = 0.510, p = 0.006) predicted higher TNF-α than the counterparts. DISCUSSION: These findings suggest inflammatory responses may be associated with providing care to an HSCT recipient, especially in caregivers who take medications, provide more hours of care a day and care for patients with hematologic malignancies. The results highlight a physiological response of stress and bring to light the importance of developing interventions focused on reducing time spent caregiving, such as a respite care program for family caregivers.
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