Evidence map›Paper›PMID 40215964›Full record

ArticleCurrent biology : CB2025

A sensitive period for the development of episodic-like memory in mice.

Adam I Ramsaran, Silvia Ventura, Julia Gallucci, Mitchell L De Snoo, Sheena A Josselyn, Paul W Frankland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Adam I RamsaranNeurosciences & Mental Health Program, The Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada; Department of Psychology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Silvia VenturaNeurosciences & Mental Health Program, The Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada.
Julia GallucciNeurosciences & Mental Health Program, The Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada.
Mitchell L De SnooNeurosciences & Mental Health Program, The Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.
Sheena A JosselynNeurosciences & Mental Health Program, The Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada; Department of Psychology, University of Toronto, Toronto, ON M5S 1A8, Canada; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Paul W FranklandNeurosciences & Mental Health Program, The Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada; Department of Psychology, University of Toronto, Toronto, ON M5S 1A8, Canada; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Child & Brain Development Program, Canadian Institute for Advanced Research, 661 University Ave., Toronto, ON M5G 1M1, Canada. Electronic address: paul.frankland@sickkids.ca.

Funding

The Role of Neuronal Ensembles Supporting Auditory Fear Conditioning (Engrams) in the Amygdala in Memory Formation, Generalization and ExtinctionR01MH119421 · NIMH · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI FRANKLAND, PAUL, JOSSELYN, SHEENA A · 2019 to 2023
$1.7M
Developmental Regulation of Memory Specificity by the Brain Extracellular MatrixF31MH120920 · NIMH · UNIVERSITY OF TORONTO · PI RAMSARAN, ADAM I · 2019 to 2020
$66k
NIMH NIH HHS F31 MH120920NIMH NIH HHS R01 MH119421
6 · The paper itself

Abstract

Episodic-like memory is a later-developing cognitive function supported by the hippocampus. In mice, the formation of extracellular perineuronal nets in subfield cornu ammonis (CA) 1 of the dorsal hippocampus controls the emergence of episodic-like memory during the fourth post-natal week. Whether the timing of episodic-like memory onset is hard-wired, or flexibly set by early-life experiences during a critical or sensitive period for hippocampal maturation, is unknown. Here, we show that the trajectories for episodic-like memory development vary for mice given different sets of experiences spanning the second and third post-natal weeks. Specifically, episodic-like memory precision developed later in mice that experienced early-life adversity, while it developed earlier in mice that experienced early-life enrichment. Moreover, we demonstrate that early-life experiences set the timing of episodic-like memory development by modulating the pace of perineuronal net formation in dorsal CA1, which is dependent on the brain-derived neurotrophic factor (BDNF)-tropomysin receptor kinase B (TrkB) signaling pathway. These results indicate that the hippocampus undergoes a sensitive period during which early-life experiences determine the timing for episodic-like memory development.

Indexed as

CA1 Region, HippocampalHippocampusMemory, EpisodicAnimalsBrain-Derived Neurotrophic FactorFemaleMaleMiceMice, Inbred C57BLReceptor, trkBSignal TransductionBdnf protein, mouseBrain-Derived Neurotrophic FactorNtrk2 protein, mouseReceptor, trkBcritical perioddevelopmentearly-life experienceengramextracellular matrixhippocampusmemoryperineuronal netsensitive period

Identifiers

PMID40215964
PMCPMC12055481

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.