ArticleJournal of the American Chemical Society2025
Magnetite Nanodiscs Activate Mechanotransductive Calcium Signaling in Diverse Cell Types.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Targeted Magnetic Nanodiscs for Wireless Causal Manipulation of Gut-Brain Circuits.bioRxiv : the preprint server for biology · 2026Article
- Multifunctional FePharmaceutics · 2026Article
- On Vibronic-Driven Action and Mechanosensitive G Protein-Coupled Receptors.International journal of molecular sciences · 2026Review
- Nanoparticles-Mediated Modulation of TRP Channels: Advances and Therapeutic Potential.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
Remote magnetomechanical stimulation using magnetic nanomaterials has emerged as a robust and minimally invasive technique for modulating neuronal activity. However, despite the presence of machinery to convert mechanical force into biochemical signals in many types of cells, magnetomechanical stimulation of non-neuronal tissue remains largely unexplored. Here, we demonstrate that in the presence of weak magnetic fields (12-56 mT) with frequencies 5-125 Hz, magnetite nanodiscs (MNDs) activate ubiquitous mechano-sensitive calcium signaling pathways, including transmembrane calcium entry, the release of intracellular calcium reserves, and store-operated calcium signaling. MNDs mediate calcium transients in cells with disparate calcium signaling machinery, such as cardiomyocytes and hippocampal astrocytes. The characteristics of these calcium responses depend on the protein machinery available in each cell type. These findings expand the reach of cellular modulation strategies using magnetic nanoparticles to non-neuronal cells and thereby open new applications probing endocrine, immune, and circulatory functions and related disorders with remote magnetic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.