Evidence map›Paper›PMID 40215358›Full record

ArticleJournal of the American Chemical Society2025

Biomimetic Total Synthesis and Paired Omics Identify an Intermolecular Diels-Alder Reaction as the Key Step in Lugdunomycin Biosynthesis.

Michiel T Uiterweerd, Isabel Nuñez Santiago, Ana V Cunha, Remco W A Havenith, Chao Du, Le Zhang, Helga U van der Heul, Somayah S Elsayed, Adriaan J Minnaard, Gilles P van Wezel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Synthetic and systems biotechnology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michiel T UiterweerdStratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, Groningen 9747 AG, The Netherlands.
Isabel Nuñez SantiagoInstitute of Biology, Leiden University, Sylviusweg 72, Leiden 2333 BE, The Netherlands.
Ana V CunhaFaculty of Engineering, University of Antwerp, IPRACS, Groenenborgerlaan 171, Antwerpen 2020, Belgium.ORCID 0000-0001-8996-2860
Remco W A HavenithStratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, Groningen 9747 AG, The Netherlands.ORCID 0000-0003-0038-6030
Chao DuInstitute of Biology, Leiden University, Sylviusweg 72, Leiden 2333 BE, The Netherlands.ORCID 0000-0003-3447-5293
Le ZhangInstitute of Biology, Leiden University, Sylviusweg 72, Leiden 2333 BE, The Netherlands.
Helga U van der HeulInstitute of Biology, Leiden University, Sylviusweg 72, Leiden 2333 BE, The Netherlands.
Somayah S ElsayedInstitute of Biology, Leiden University, Sylviusweg 72, Leiden 2333 BE, The Netherlands.ORCID 0000-0003-3837-6137
Adriaan J MinnaardStratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, Groningen 9747 AG, The Netherlands.ORCID 0000-0002-5966-1300
Gilles P van WezelInstitute of Biology, Leiden University, Sylviusweg 72, Leiden 2333 BE, The Netherlands.ORCID 0000-0003-0341-1561

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbial natural products are the basis of the majority of clinical drugs, where the discovery of truly novel structural scaffolds to fill the discovery pipelines is a prerequisite. Lugdunomycin is a highly rearranged angucycline polyketide produced by

Indexed as

BiomimeticsStreptomycesCycloaddition ReactionMultigene Family

Identifiers

PMID40215358
PMCPMC12022981

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.