Evidence map›Paper›PMID 40215325›Full record

ArticleScience immunology2025

Foxo1 regulates intestinal tissue-resident memory CD8 T cell biology in an anatomic compartment- and context-specific manner.

Paul Hsu, Eunice J Choi, William H Wong, Yun Hsuan Lin, Sara A Vandenburgh, Yi Chia Liu, Priscilla Yao, Cynthia S Indralingam, Gene W Yeo, Elina I Zuniga and 3 more

Abstract read
In one paragraph

Article in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Paul HsuDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-9365-9565
Eunice J ChoiDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
William H WongDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0009-0009-7090-6354
Yun Hsuan LinDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0009-0008-5997-9109
Sara A VandenburghDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0009-0007-3074-8326
Yi Chia LiuDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Priscilla YaoDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Cynthia S IndralingamDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Gene W YeoDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-0799-6037
Elina I ZunigaDivision of Biological Sciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-8699-1623
Ananda W GoldrathDivision of Biological Sciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-5900-508X
Wei WangDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-4377-5060
John T ChangDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-0873-6218

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
Single-Cell Transcriptomic and Epigenetics CoreP01AI132122 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZUNIGA, ELINA I · 2018 to 2022
$9.8M
Positive Immune-regulators During Chronic Viral InfectionsR01AI113923 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZUNIGA, ELINA I · 2015 to 2024
$5.1M
Rheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8M
Systems-level identification of key regulators deciding immune cell stateR01AI150282 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, WEI · 2020 to 2024
$3.5M
Using single-cell RNA-seq to interrogate host immunity to pathogensR01AI123202 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, JOHN T, YEO, EUGENE WEI-MING · 2016 to 2020
$3.1M
Role of proteasome activity in adaptive immunityR01AI129973 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, JOHN T · 2018 to 2022
$2.2M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
The role of mitochondria in skeletal muscle fatigue caused by cancer chemotherapyF32AR061946 · NIAMS · EAST CAROLINA UNIVERSITY · PI GILLIAM, LAURA ANN ASHLEY · 2012 to 2014
$114k
BLRD VA I01 BX005106CSRD VA I01 CX002396NCI NIH HHS P30 CA023100NIAID NIH HHS P01 AI132122NIAID NIH HHS R01 AI113923NIAID NIH HHS R01 AI123202NIAID NIH HHS R01 AI129973NIAID NIH HHS R01 AI150282NIAMS NIH HHS F32 AR061946NIAMS NIH HHS T32 AR064194NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK120515NIH HHS S10 OD026929
6 · The paper itself

Abstract

Tissue-resident memory CD8 T (T

Indexed as

CD8-Positive T-LymphocytesForkhead Box Protein O1Immunologic MemoryIntestinal MucosaAnimalsMiceMice, Inbred C57BLMice, KnockoutForkhead Box Protein O1Foxo1 protein, mouse

Identifiers

PMID40215325
PMCPMC12955362

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.