Observational studyPloS one2025
Effect of caffeine citrate on diaphragmatic electrical activity in pre-term newborns.
Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gold standard treatment for apnea of prematurity is caffeine citrate, which is known for its effect on diaphragm muscle activity. The purpose of this study was to investigate the electrical activity of the diaphragm in preterm newborns, which was measured 30 minutes before and 60 minutes after the administration of a loading dose of caffeine citrate. In this prospective, observational, longitudinal study at a tertiary-level neonatal ICU, data were collected from 36 patients (13 females, 23 males) with a mean gestational age of 31 2/7 ± 2 1/7 weeks and a mean birth weight of 1532 ± 439 grams. The average caffeine level was 15.7 ± 5.9 mg/dL (reference range: 5-30 mg/dL). The results revealed significant increases in all the parameters used to determine the inspiratory phases of the respiratory cycle postcaffeine administration (p < 0.001). The study concluded that caffeine administration significantly enhances diaphragmatic electrical activity in preterm newborns.
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