Evidence map›Paper›PMID 40215098›Full record

ArticleeLife2025

Mechanisms that regulate the C1-C2B mutual inhibition control functional switch of UNC-13.

Haowen Liu, Lei Li, Jiafan Wang, Jiayi Hu, Jingyao Xia, Xiaochun Yu, Jing Tang, Huisheng Liu, Xiaofei Yang, Cong Ma and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Munc13-1 couples DAG and CaScience advances · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Haowen Liu *Department of Neuroscience, City University of Hong Kong, Kowloon, China.ORCID https://orcid.org/0000-0001-8498-290X
Lei Li *Department of Neuroscience, City University of Hong Kong, Kowloon, China.
Jiafan WangDepartment of Neuroscience, City University of Hong Kong, Kowloon, China.
Jiayi HuDepartment of Neuroscience, City University of Hong Kong, Kowloon, China.
Jingyao XiaQueensland Brain Institute, The University of Queensland, Brisbane, Australia.
Xiaochun YuDepartment of Neuroscience, City University of Hong Kong, Kowloon, China.
Jing TangNeuroscience Research Center, Key Laboratory of Biomedical Information Engineering of Ministry of Education,School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.
Huisheng LiuSchool of Biomedical Engineering, Guangzhou Medical University; Guangzhou National Laboratory; Bioland Laboratory, Guangzhou, China.
Xiaofei YangKey Laboratory of Cognitive Science, Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis & Treatment, Laboratory of Membrane Ion Channels and Medicine, College of Biomedical Engineering, South-Central Minzu University, Wuhan, China.
Cong MaKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0000-0002-7814-0500
Lijun KangDepartment of Neurology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, China.ORCID https://orcid.org/0000-0001-9939-5134
Zhitao HuDepartment of Neuroscience, City University of Hong Kong, Kowloon, China.ORCID https://orcid.org/0000-0002-2948-3339

Funding

Investigating the coordinated functions of a dual Ca2+ sensor system in C. elegansR56NS128048 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI RICHMOND, JANET E · 2022 to 2022
$351k
City University of Hong Kong 9610647National Health and Medical Research Council APP1122351NIH HHS R56NS128048NINDS NIH HHS R56 NS128048
6 · The paper itself

Abstract

Munc13 plays a crucial role in short-term synaptic plasticity by regulating synaptic vesicle (SV) exocytosis and neurotransmitter release at the presynaptic terminals. However, the intricate mechanisms governing these processes have remained elusive due to the presence of multiple functional domains within Munc13, each playing distinct roles in neurotransmitter release. Here, we report a coordinated mechanism in the

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsNerve Tissue ProteinsSynaptic TransmissionAnimalsDiglyceridesExocytosisMutationPhosphatidylinositol 4,5-DiphosphateSynaptic VesiclesCaenorhabditis elegans ProteinsDiglyceridesNerve Tissue ProteinsPhosphatidylinositol 4,5-DiphosphateC. elegansMunc13neurosciencesynaptic transmissionUNC-13

Identifiers

PMID40215098
PMCPMC11991699

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.