Evidence map›Paper›PMID 40214911›Full record

ArticleCardiovascular toxicology2025

AhR Activation at the Air-Blood Barrier Alters Systemic microRNA Release After Inhalation of Particulate Matter Containing Environmentally Persistent Free Radicals.

Ankit Aryal, Ashlyn C Harmon, Alexandra Noël, Qingzhao Yu, Kurt J Varner, Tammy R Dugas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ankit AryalDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA.
Ashlyn C HarmonDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA.
Alexandra NoëlDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA.
Qingzhao YuBiostatistics, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.
Kurt J VarnerDepartment of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.
Tammy R DugasDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA. tammydugas@lsu.edu.

Funding

Role of microbiota in increased influenza severity due to particulate matter exposureP42ES013648 · NIEHS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI MERCANTE, DONALD E · 2009 to 2024
$27.6M
NIEHS NIH HHS P42 ES013648NIEHS NIH HHS P42ES013648
6 · The paper itself

Abstract

Particulate matter containing environmentally persistent free radicals (EPFRs) is formed when organic pollutants are incompletely burned and adsorb to the surface of particles containing redox-active metals. Our prior studies showed that in mice, EPFR inhalation impaired vascular relaxation in a dose- and endothelium-dependent manner. We also observed that activation of the aryl hydrocarbon receptor (AhR) in the alveolar type-II (AT-II) cells that form the air-blood interface stimulates the release of systemic factors that promote endothelial dysfunction in vessels peripheral to the lung. AhR is a recognized regulator of microRNA (miRNA) biogenesis, and miRNA control diverse signaling pathways. We thus hypothesized that systemic EPFR-induced vascular endothelial dysfunction is initiated via AhR activation in AT-II cells, resulting in a systemic release of miRNA. Using a combustion reactor, we generated EPFR of two free radical concentrations-EPFR

Indexed as

Air PollutantsAlveolar Epithelial CellsBasic Helix-Loop-Helix ProteinsBlood-Air BarrierCirculating MicroRNAEndothelium, VascularMicroRNAsParticulate MatterReceptors, Aryl HydrocarbonAnimalsCell LineFree RadicalsInhalation ExposureMaleMiceMice, Inbred C57BLAhr protein, mouseAir PollutantsBasic Helix-Loop-Helix ProteinsCirculating MicroRNAFree RadicalsMicroRNAsParticulate MatterReceptors, Aryl HydrocarbonAir pollutionAlveolar type-II cellsAryl hydrocarbon receptorCardiovascular healthEnvironmentally persistent free radicalsEnvironmental toxicologyInhalationmicroRNAParticulate matter

Identifiers

PMID40214911
PMCPMC12018632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.