Evidence map›Paper›PMID 40214888›Full record

ArticleNeurocritical care2025

The Influence of Different Arterial Carbon Dioxide Levels on the Cerebrovascular Autoregulation Curve in a Porcine Cranial Window Model.

Sofie Dietvorst, Bavo Kempen, Veerle De Sloovere, Nikky Corthout, Geert Meyfroidt, Bart Depreitere

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Article in Neurocritical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Sofie DietvorstDepartment of Neurosurgery, University Hospitals Leuven, Leuven, Belgium. sofie.dietvorst@alderhey.nhs.uk.ORCID 0000-0002-9926-4529
Bavo KempenLaboratory of Experimental Neurosurgery and Neuroanatomy, KU Leuven, Leuven, Belgium.
Veerle De SloovereDepartment of Anesthesiology, University Hospitals Leuven, Leuven, Belgium.
Nikky CorthoutLaboratory of Molecular Neurobiology, VIB-KU Leuven, Leuven, Belgium.
Geert MeyfroidtLaboratory of Intensive Care Medicine, KU Leuven, Leuven, Belgium.
Bart DepreitereDepartment of Neurosurgery, University Hospitals Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCerebrovascular autoregulation (CA) is the ability to maintain adequate cerebral blood flow (CBF) over a wide range of arterial blood pressures (ABPs). Carbon dioxide (CO

methodsA porcine cranial window model, in which CBF can be measured directly in the pial arterioles while ABP is mechanically manipulated, is used to investigate the effect of partial pressure of CO

resultsBefore ABP manipulation, hypercapnia already induced significant vasodilation (+ 33.9%) and an increase in CBF (+ 20.5%), whereas hypocapnia did not alter diameter or CBF. Both hypercapnia and hypocapnia significantly reduced the ability to adjust arteriolar diameters in response to changes in ABP.

conclusionsDuring hypocapnia as well as hypercapnia, narrowing of the CA range with a shorter plateau between the upper and lower limit of autoregulation was observed, compared to normocapnia.

Indexed as

Arterial PressureCarbon DioxideCerebrovascular CirculationHomeostasisHypercapniaHypocapniaAnimalsArteriolesDisease Models, AnimalMaleModels, AnimalSwineVasodilationCarbon DioxideArterial carbon dioxide pressureCerebrovascular autoregulationCerebrovascular resistancePorcine cranial window modelVentilation

Identifiers

PMID40214888

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.