ArticleMagma (New York, N.Y.)2025
Influence of orientation, size and shape of the region of interest in diffusion MRI along perivascular spaces index.
Article in Magma (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Imaging biomarkers of glymphatic system dysfunction in Alzheimer's disease: a systematic review and meta-analysis with a focus on DTI-ALPS index.Frontiers in aging neuroscience · 2026Pooled it
- DTI-ALPS as a marker of glymphatic function: Review of the literature findings, methodology, and interpretation.Neuroimage. Reports · 2026Article
- DTI-ALPS is not independently associated with overall survival beyond established prognostic factors in glioblastoma.Journal of neuro-oncology · 2026Article
- Diffusion tensor image analysis along the perivascular space may serve as a potential biomarker for differentiating glioma recurrence from pseudoprogression: a preliminary study.Quantitative imaging in medicine and surgery · 2026Article
- Automatic determination of glymphatic flow with the DTI-ALPS-index along the principal axis system in native imaging space corrects for head and fiber orientation.Magnetic resonance in medicine · 2026Article
- Hemodialysis and its effects on glymphatic system function in end-stage kidney disease patients.Quantitative imaging in medicine and surgery · 2025Article
- Longitudinal changes in the ALPS index and its clinical correlates in patients with basal ganglia hemorrhage.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDiffusion-tensor imaging (DTI) and diffusion-weighted imaging (DWI) along perivascular spaces (ALPS) index have been proposed as noninvasive techniques to indirectly evaluate the glymphatic system function. However, these techniques are sensitive to examination parameters, limiting inter-study comparability. The definition of the region of interest (ROI) has been identified as the primary weakness of the ALPS method. Therefore, we aimed to determine which ROI characteristics would best promote consistent ALPS index analysis.
methodsWe examined 13 healthy volunteers using DTI and DWI to calculate the ALPS index, and compared and determined correlations among 11 different ROI configurations, and tested inter-method reliability.
resultsWe found significant differences between different ROI configurations in the ALPS index calculation. Considering ROI characteristics and inter-method reliability, a squared ROI is the most suitable. The ICC between ROI configurations showed good-to-excellent inter-method agreement (mean ICC = 0.83). We did not find significant inter-method differences.
conclusionIt is important to standardize the ROI characteristics for consistent ALPS index calculation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.