Evidence map›Paper›PMID 40214842›Full record

ArticleTropical animal health and production2025

Genome-wide association study applied to prolificacy in Santa Inês sheep.

Luis Andrés Salazar Caraballo, Luiz Antônio Silva Figueiredo Filho, Luciano Silva Sena, Daniel Biagiotti, José Dos Santos de Moura, Antônio de Sousa Júnior, Artur Oliveira Rocha, Fabiana Cristina Belchior de Sousa, Natanael Pereira da Silva Santos, José Lindenberg Rocha Sarmento

Abstract read
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In one paragraph

Article in Tropical animal health and production, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Luis Andrés Salazar CaraballoAgrarian Sciences Center (CCA), Federal University of Piauí (UFPI), Campus Universitário Ministro Petrônio Portella, Teresina, PI, Brazil.ORCID http://orcid.org/0000-0001-9056-9644
Luiz Antônio Silva Figueiredo FilhoFederal Institute of Education, Science and Technology of MaranhãO, IFMA, Caxias, MA, Brazil.ORCID http://orcid.org/0000-0003-3204-1109
Luciano Silva SenaPhd in Animal Science, Graduate Program in Animal Science, Agrarian Sciences Center (CCA), UFPI, Campus Universitário Ministro Petrônio Portella, Teresina, Brazil.ORCID http://orcid.org/0000-0003-0054-6655
Daniel BiagiottiTechnical College of Teresina, UFPI, Campus Ministro Petrônio Portella, Teresina, PI, Brazil.ORCID http://orcid.org/0000-0001-7828-1955
José Dos Santos de MouraFederal Institute of Education, Science and Technology of Piauí, IFPI, José de Freitas, PI, Brazil.ORCID http://orcid.org/0000-0003-3310-145X
Antônio de Sousa JúniorTechnical College of Teresina, UFPI, Campus Ministro Petrônio Portella, Teresina, PI, Brazil.ORCID http://orcid.org/0000-0002-3651-8093
Artur Oliveira RochaDepartment of Animal Science, Purdue University, West Lafayette, 47907, USA.ORCID http://orcid.org/0000-0002-9021-2925
Fabiana Cristina Belchior de SousaDepartment of Animal Science, CCA, UFPI, Campus Ministro Petrônio Portella, Teresina, PI, Brazil. fabiana.cristina1@hotmail.com.ORCID http://orcid.org/0000-0002-3829-0627
Natanael Pereira da Silva SantosDepartment of Animal Science, CCA, UFPI, Campus Ministro Petrônio Portella, Teresina, PI, Brazil.ORCID http://orcid.org/0000-0002-7538-5000
José Lindenberg Rocha SarmentoDepartment of Animal Science, CCA, UFPI, Campus Ministro Petrônio Portella, Teresina, PI, Brazil.ORCID http://orcid.org/0000-0002-4215-1515

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to identify genomic regions associated with prolificacy in Santa Inês sheep raised in tropical conditions. The prolificacy of the dam was defined as single (only one lamb born per ewe per lambing) or multiple (more than one animal born per ewe per lambing). After quality control of phenotypic data, 1584 lambing records of 715 females occurred between the years 2000 and 2018 were used. The animals were genotyped with the OvineSNP50 BeadChip panel (Illumina Inc.). After quality control of genomic data, information of 46,714 SNPs and 388 samples and females was used for the subsequent analyses. The single-step GWAS (ssGWAS) methodology was used to estimate the effects of genetic markers and their association with the prolificacy. A total of 21 windows of 10 adjacent SNPs that explained at least 0.5% of the additive genetic variance for prolificacy were identified. In such regions, genes associated with different reproductive functions in the female were found: CACNA1E, NTRK1, PLCH1, SMAD3, CENPF, TOPBP1, IL33, DRD2, MID1, HCCS, and ARHGAP6. Some candidate regions related to prolificacy harbor genes that were not previously described and genes without known functions. These results can help to identify genes associated with prolificacy and could be used in genomic reproductive studies on prolificacy, as well as in the selection of the most prolific ewes in the population.

Indexed as

Genome-Wide Association StudyReproductionSheep, DomesticAnimalsFemaleGenetic MarkersGenotypePolymorphism, Single NucleotideGenetic MarkersGenesHair sheepMultiple lambingSNPSsGWAS

Identifiers

PMID40214842

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.