Evidence map›Paper›PMID 40214794›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Persistent opioid use is associated with a shorter myeloma survival.

Karen Sweiss, Ana Maria Avila Rodriguez, John G Quigley, Lisa Sharp, Kaily Kurzweil, Jaleel G Sweis, Gregory S Calip, Zacharie Hamilton, Chukwuemeka Uzoka, Elizabeth Ilo and 5 more

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In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Opioids or Munaciello... (a little monk).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Karen SweissDepartment of Pharmacy Practice, College of Pharmacy, University of Illinois, 833 South Wood Street, Chicago, IL, 60612, USA. ksweis2@uic.edu.ORCID http://orcid.org/0000-0001-9559-0282
Ana Maria Avila RodriguezDivision of Hematology/ Oncology, University of Illinois at Chicago, Chicago, IL, USA.
John G QuigleyDivision of Hematology/ Oncology, University of Illinois at Chicago, Chicago, IL, USA.
Lisa SharpCenter for Pharmacoepidemiology and Pharmacoeconomic Research, University of Illinois at Chicago, Chicago, IL, USA.
Kaily KurzweilBone Marrow Transplant and Cellular Therapy, Northwestern Memorial Hospital, Chicago, IL, USA.
Jaleel G SweisDivision of Hematology/ Oncology, University of Illinois at Chicago, Chicago, IL, USA.
Gregory S CalipCenter for Pharmacoepidemiology and Pharmacoeconomic Research, University of Illinois at Chicago, Chicago, IL, USA.
Zacharie HamiltonDivision of Hematology/ Oncology, University of Illinois at Chicago, Chicago, IL, USA.
Chukwuemeka UzokaDivision of Hematology/ Oncology, University of Illinois at Chicago, Chicago, IL, USA.
Elizabeth IloDepartment of Pharmacy Practice, College of Pharmacy, University of Illinois, 833 South Wood Street, Chicago, IL, 60612, USA.
Elliot WolfDepartment of Pharmacy Practice, College of Pharmacy, University of Illinois, 833 South Wood Street, Chicago, IL, 60612, USA.
Damiano RondelliDivision of Hematology/ Oncology, University of Illinois at Chicago, Chicago, IL, USA.
Douglas W SborovDivision of Hematology and Hematologic Malignancies, Huntsman Cancer Institute at the University Salt, Lake City, UT, USA.
Pritesh Patel *Division of Hematology/ Oncology, University of Illinois at Chicago, Chicago, IL, USA.
Craig C Hofmeister *Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOveruse of opioids has been associated with a significant public health crisis, yet remain critical as adjunctive treatment in multiple myeloma (MM). Questions remain about the balance between the benefits to risks of ongoing opioid use, especially when the patient's myeloma is in remission. This retrospective review focuses on the association of chronic opioid use (COU) in a patient population predominantly people of color.

methodsA cohort of 174 MM patients who received autologous stem cell transplant (ASCT) at an urban medical center were studied.

resultsBaseline COU was observed in 52.9% of patients. COU rates and average morphine milligram equivalents (MME) per day were similar in those with and without bone disease. Previous illicit drug use was associated with a higher baseline COU. 142 (81.6%) patients received opioids during ASCT admission, while 105 (60.3%) were discharged on opioids and 72 (41.4%) met criteria for COU at 6 months. Opioid use at hospital discharge was associated with a higher 6-month COU (p = 0.008). COU at 6 months was independently associated with worse overall survival (p = 0.006).

conclusionWe describe high rates of baseline COU in MM unrelated to bone disease. A number of patients started opioids during ASCT and were still taking them at 6-month follow-up visit. We demonstrate a negative association of 6-month COU on OS but not on PFS suggesting that opioid-related morbidity may play a role. These data highlight the need to test causality of opioid use on survival while simultaneously improving the management of pain in MM.

Indexed as

Analgesics, OpioidCancer PainMultiple MyelomaAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesStem Cell TransplantationTransplantation, AutologousAnalgesics, OpioidAutologous transplantMultiple myelomaOpioidsPain

Identifiers

PMID40214794
PMCPMC11991991

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.