ArticleArchives of virology2025
Molecular evolution of coxsackievirus A6 associated with atypical hand, foot, and mouth disease in Northern Brazil in 2019.
Article in Archives of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Global epidemiological and aetiological patterns of hand, foot, and mouth disease: a country-level scoping synthesis.Journal of global health · 2026Article
- Evolutionary dynamics of coxsackievirus A24 variant associated with acute hemorrhagic conjunctivitis in Brazil.Scientific reports · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
Globally, coxsackievirus A6 (CVA6) is a major cause of hand, foot, and mouth disease (HFMD) outbreaks, although studies on its evolutionary and transmission dynamics are limited. Here, we analyzed samples from atypical HFMD cases in Brazil. Enteroviruses were detected in 49.2% (156/317) of the specimens, with CVA6 being the primary pathogen. Phylogenetic analysis based on VP1 gene sequences revealed that Brazilian CVA6 isolates belonged to the lineage D3 and were divided into two distinct clades from different regions. Temporal analysis indicated that the most recent common ancestor dates back 72 years and that there has been stable coevolution of genotypes. These findings shed light on the epidemiological dynamics of CVA6 and highlight the importance of surveillance of atypical HFMD cases.
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