Evidence map›Paper›PMID 40214714›Full record

ArticleSleep & breathing = Schlaf & Atmung2025

Detecting arousals and sleep from respiratory inductance plethysmography.

Eysteinn Finnsson, Ernir Erlingsson, Hlynur D Hlynsson, Vaka Valsdóttir, Thora B Sigmarsdottir, Eydís Arnardóttir, Scott A Sands, Sigurður Æ Jónsson, Anna S Islind, Jón S Ágústsson

Abstract read
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Validation of a deep learning-based system for sleep staging, arousal detection, and respiratory event scoring in atrial fibrillation patients.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Article
  2. From classic to cutting-edge: technological approaches to respiratory physiological signals in assessing sleep-disordered breathing.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eysteinn Finnsson *Nox Research, Nox Medical, Katrínartún 2, 105, Reykjavík, Iceland. eysteinnf@noxmedical.com.ORCID 0000-0001-7396-0713
Ernir Erlingsson *Nox Research, Nox Medical, Katrínartún 2, 105, Reykjavík, Iceland.ORCID 0000-0003-2867-6291
Hlynur D HlynssonNox Research, Nox Medical, Katrínartún 2, 105, Reykjavík, Iceland.ORCID 0000-0002-9487-8054
Vaka ValsdóttirNox Research, Nox Medical, Katrínartún 2, 105, Reykjavík, Iceland.ORCID 0000-0003-3642-6313
Thora B SigmarsdottirNox Research, Nox Medical, Katrínartún 2, 105, Reykjavík, Iceland.ORCID 0000-0002-4737-4646
Eydís ArnardóttirNox Research, Nox Medical, Katrínartún 2, 105, Reykjavík, Iceland.ORCID 0000-0002-9245-5779
Scott A SandsDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3752-0328
Sigurður Æ JónssonNox Research, Nox Medical, Katrínartún 2, 105, Reykjavík, Iceland.ORCID 0009-0004-7765-4018
Anna S IslindDepartment of Computer Science, Reykjavik University, Reykjavik, Iceland.ORCID 0000-0002-4563-0001
Jón S ÁgústssonNox Research, Nox Medical, Katrínartún 2, 105, Reykjavík, Iceland.ORCID 0000-0003-4309-6439

Funding

Role of ventilatory drive in obstructive sleep apnea: An avenue for precision interventionR01HL168067 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Scott A Sands · 2023 to 2026
$3.5M
A Novel Pharmacological Therapy for Obstructive Sleep ApneaR01HL146697 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SANDS, SCOTT A · 2019 to 2023
$3.4M
American Academy of Sleep Medicine Foundation 228-SR-20NHLBI NIH HHS R01 HL146697NHLBI NIH HHS R01HL146697NHLBI NIH HHS R01 HL168067NHLBI NIH HHS R01HL168067
6 · The paper itself

Abstract

purposeAccurately identifying sleep states (REM, NREM, and Wake) and brief awakenings (arousals) is essential for diagnosing sleep disorders. Polysomnography (PSG) is the gold standard for such assessments but is costly and requires overnight monitoring in a lab. Home sleep testing (HST) offers a more accessible alternative, relying primarily on breathing measurements but lacks electroencephalography, limiting its ability to evaluate sleep and arousals directly. This study evaluates a deep learning algorithm which determines sleep states and arousals from breathing signals.

methodsA novel deep learning algorithm was developed to classify sleep states and detect arousals from respiratory inductance plethysmography signals. Sleep states were predicted for 30-s intervals (one sleep epoch), while arousal probabilities were calculated at 1-s resolution. Validation was conducted on a clinical dataset of 1,299 adults with suspected sleep disorders. Performance was assessed at the epoch level for sensitivity and specificity, with agreement analyses for arousal index (ArI) and total sleep time (TST).

resultsThe algorithm achieved sensitivity and specificity of 77.9% and 96.2% for Wake, 93.9% and 80.4% for NREM, 80.5% and 98.2% for REM, and 66.1% and 86.7% for arousals. Bland-Altman analysis showed ArI limits of agreement ranging from - 32 to 24 events/hour (bias: - 4.4) and TST limits from - 47 to 64 min (bias: 8.0). Intraclass correlation was 0.74 for ArI and 0.91 for TST.

conclusionThe algorithm identifies sleep states and arousals from breathing signals with agreement comparable to established variability in manual scoring. These results highlight its potential to advance HST capabilities, enabling more accessible, cost-effective and reliable sleep diagnostics.

Indexed as

ArousalDeep LearningPlethysmographyPolysomnographySleepAdultAlgorithmsFemaleHumansMaleMiddle AgedSensitivity and SpecificitySleep StagesHome sleep testingMachine learningPolysomnographySleep disordersSleep stage

Identifiers

PMID40214714
PMCPMC11991959

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.