ReviewLasers in medical science2025
Immunomodulatory effects of photobiomodulation: a comprehensive review.
Review in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Do Laser and Light Activation Improve In-Office Dental Bleaching Outcomes? An Umbrella Review of Efficacy, Tooth Sensitivity, and Biological Safety.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026Pooled it
- Clinical dosimetry and efficacy of LED photobiomodulation for chronic lower-limb wound healing: a systematic review of randomized trials.Lasers in medical science · 2026Pooled it
- Combined effects of photobiomodulation and osteopathic manipulation on the physical performance of young adults subjected to exercise-induced muscle damage: a randomized placebo-controlled trial.Lasers in medical science · 2026Trial
- Trial
- Visible light reprograms MSCs and T cells into tumor-suppressive states via OPN4-mediated epigenetic remodeling.Acta pharmacologica Sinica · 2026Article
- Parameter-screened LED therapy targets STAT3/IL-6 axis to attenuate tendinopathy via dual modulation of inflammation and ECM remodeling.Journal of orthopaedic surgery and research · 2026Article
- Photobiomodulation therapy reduces diabetic periodontal damage through modulation of macrophage metabolism and functions.Lasers in medical science · 2026Article
- Harnessing nature's blueprint: Unlocking the potential of subcellular structure membrane-coated nanosystems for precision medicine.Bioactive materials · 2026Review
- Photobiomodulation and Low-Level Laser Therapy as Complementary Strategies in Diabetes Treatment.International journal of molecular sciences · 2026Review
- Therapeutic Potential of Extracellular Vesicles: From Biogenesis, Isolation and Molecular Characterization to Addressing Translational Gaps and Regulatory Barriers.International journal of molecular sciences · 2026Review
- Photobiomodulation as an adjuvant for pain relief and healing pre-orthodontic mandibular third molar surgery: double-blinded randomized clinical trial.The Saudi dental journal · 2026Article
- Article
- Five-Year Follow-Up of Photobiomodulation in Parkinson's Disease: A Case Series Exploring Clinical Stability and Microbiome Modulation.Journal of clinical medicine · 2026Article
- Comparative clinical efficacy of photobiomodulation therapy and topical corticosteroids for oral lichen planus.Bioinformation · 2026Article
- Adjunctive photodynamic therapy improves outcomes and quality of life in condyloma acuminatum after radical cervical cancer surgery.Frontiers in oncology · 2026Article
- Abdominal Photobiomodulation and the Gut-Brain Axis: A Systematic Review of Mechanistic and Translational Evidence.Biomedicines · 2025Review
- Comments on "Immunomodulatory effects of photobiomodulation: a comprehensive review.Lasers in medical science · 2025Article
- Looking Inwards: The Role of Self-Care, Self-Management and Self-Healing in Musculoskeletal Pain.Musculoskeletal care · 2025Article
- Laser Interventions for Intraoral Halitosis: A Systematic Review of Randomized Controlled Trials.Pharmaceutics · 2025Review
- Clinical efficacy of ultra-laser irradiation combined with gabapentin on elderly patients with cervical spondylotic radiculopathy.Frontiers in neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photobiomodulation, also known as low-level light therapy (LLLT), has emerged as a promising non-invasive treatment modality with significant immunomodulatory effects. This comprehensive review examines the mechanisms underlying photobiomodulation-induced immunomodulation, its effects on specific immune cells, and its clinical applications in immune-related conditions. We explore the cellular and molecular pathways affected by photobiomodulation, including mitochondrial function, reactive oxygen species production, and key signaling cascades. The impact of photobiomodulation on macrophages, T cells, and dendritic cells is discussed, along with its potential in managing autoimmune diseases, inflammatory conditions, and wound healing. Safety considerations, optimal treatment parameters, and future directions in the field are also addressed. This review highlights the growing body of evidence supporting photobiomodulation as a valuable tool in immunomodulation and its potential to revolutionize the treatment of various immune-mediated disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.