Evidence map›Paper›PMID 40214587›Full record

ReviewNanomaterials (Basel, Switzerland)2025

Synthesis, Characterization, Magnetic Properties, and Applications of Carbon Dots as Diamagnetic Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agents: A Review.

Endale Mulugeta, Tirusew Tegafaw, Ying Liu, Dejun Zhao, Ahrum Baek, Jihyun Kim, Yongmin Chang, Gang Ho Lee

Abstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Endale MulugetaDepartment of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea.ORCID 0000-0002-2869-0934
Tirusew TegafawDepartment of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea.ORCID 0000-0001-7730-5636
Ying LiuDepartment of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea.ORCID 0009-0008-2826-6536
Dejun ZhaoDepartment of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea.ORCID 0009-0002-0785-049X
Ahrum BaekInstitute of Biomedical Engineering Research, Kyungpook National University, Taegu 41944, Republic of Korea.ORCID 0000-0002-6941-8259
Jihyun KimDepartment of Chemistry Education, Teachers' College, Kyungpook National University, Taegu 41566, Republic of Korea.ORCID 0000-0002-5119-6627
Yongmin ChangDepartment of Molecular Medicine, School of Medicine, Kyungpook National University, Taegu 41944, Republic of Korea.
Gang Ho LeeDepartment of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea.ORCID 0000-0001-7451-6366

Funding

National Research Foundation RS-2024-00406209National Research Foundation RS-2024-00459895
6 · The paper itself

Abstract

Carbon dots (CDs) are metal-free carbon-based nanoparticles. They possess excellent photoluminescent properties, various physical properties, good chemical stability, high water solubility, high biocompatibility, and tunable surface functionalities, suitable for biomedical applications. Their properties are subject to synthetic conditions such as pH, reaction time, temperature, precursor, and solvent. Until now, a large number of articles on the synthesis and biomedical applications of CDs using their photoluminescent properties have been reported. However, their research on magnetic properties and especially, diamagnetic chemical exchange saturation transfer (diaCEST) in magnetic resonance imaging (MRI) is very poor. The diaCEST MRI contrast agents are based on exchangeable protons of materials with bulk water protons and thus, different from conventional MRI contrast agents, which are based on enhancements of proton spin relaxations of bulk water and tissue. In this review, various syntheses, characterizations, magnetic properties, and potential applications of CDs as diaCEST MRI contrast agents are reviewed. Finally, future perspectives of CDs as the next-generation diaCEST MRI contrast agents are discussed.

Indexed as

carbon dotcharacterizationdiaCESTmagnetic propertiesMRI contrast agentsynthesis

Identifiers

PMID40214587
PMCPMC11990683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.