Evidence map›Paper›PMID 40214518›Full record

ArticleJournal of veterinary internal medicine

Prognostic Utility of F-Waves in Paraplegic Dogs With Absent Pain Perception Secondary to Intervertebral Disc Extrusion.

Go Togawa, Melissa J Lewis, Stephen R Were, R Timothy Bentley, Stephanie A Thomovsky

Abstract readMulticenter StudyObservational Study, Veterinary
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Go TogawaDepartment of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Melissa J LewisDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA.ORCID https://orcid.org/0000-0002-3829-4193
Stephen R WereDepartment of Population Health Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
R Timothy BentleyDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA.
Stephanie A ThomovskyDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA.

Funding

ACVIM Holliday Resident Research Grant
6 · The paper itself

Abstract

backgroundApproximately 50%-60% of paraplegic deep pain negative (DPN) dogs secondary to thoracolumbar intervertebral disc extrusion (TL-IVDE) recover ambulation after surgery. Mean F-wave duration has been associated with injury severity in TL-IVDE in dogs, but the relationship to outcome is unknown.

objectiveEvaluate the prognostic utility of F-waves in DPN dogs secondary to TL-IVDE treated surgically. ANIMALS: Thirty client-owned, acutely paraplegic DPN dogs secondary to TL-IVDE were managed surgically.

methodsMulti-center prospective and observational study. F-waves were performed at baseline (within 24 h post-operatively), 2-4 weeks and 3 months post-operatively. Outcome was categorized as successful or unsuccessful, with success defined as independent ambulation at 3 months post-operatively. F-wave variables were compared between dogs with a successful or unsuccessful outcome and over time using generalized estimating equations. Receiver-operating characteristic curves were generated for baseline F-wave variables.

resultsF-waves were well-tolerated in all dogs. Of 30 enrolled dogs, 12 dogs had a successful outcome, 10 dogs were unsuccessful, and 8 dogs were removed from outcome analysis (3 progressive myelomalacia, 1 severe spinal shock, 2 technical error, and 2 unknown outcome). Baseline mean F-wave duration (displayed as median (range)) was longer in unsuccessful dogs (31.7 (11.4-60.8) ms) versus successful dogs (19.6 (10.8-27.3) ms), p = 0.003. Mean F-wave duration > 28.5 ms was 70% sensitive (95% confidence interval (CI): 40%-100%) and 100% specific (95% CI: 100%-100%) in predicting an unsuccessful outcome. CONCLUSIONS AND CLINICAL IMPORTANCE: F-waves performed shortly post-operatively could aid in predicting outcomes in DPN dogs secondary to TL-IVDE treated surgically.

Indexed as

Dog DiseasesIntervertebral Disc DisplacementParaplegiaAnimalsDogsFemaleMalePrognosisProspective Studiescaninedeep pain negativeelectrodiagnosticsintervertebral disc herniation

Identifiers

PMID40214518
PMCPMC11987208

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.