ArticleEndocrine connections2025
Quality of life and psychological status in people with acromegaly in relation to facial changes.
Article in Endocrine connections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Disease-related burden and treatment experience in patients with acromegaly: a gender perspective.Journal of endocrinological investigation · 2026Article
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionThe diagnosis of acromegaly is often delayed, leading to facial disfigurements that persist despite endocrine cure. We aimed to study the relationship between facial modifications, Quality of Life (QoL), and psychologic status in patients with acromegaly.
methodsSixty-five patients in remission or with hormonal disease control participated (29 women and 36 men; mean age 57.4±13.5 years). The following variables were assessed: a) Quality of life using AcroQoL; b) Anxiety level with the STAI Questionnaire; c) Self-esteem by the Rosemberg Scale; and d) Facial acromegaly phenotypic changes evaluated from photographs by 8 experienced endocrinologists using a Likert scale.
resultsThe overall AcroQoL score showed mid-range values, with better scores for men (72.3 vs 56.6, p=0.022). AcroQoL physical domain was also higher for men (59.0 vs 34.9, p=0.006). In the psychological domain, men tended to score better (65.7 vs 54.5, p=0.069), particularly in the appearance subdimension (53.8 vs 38.8, p=0.07), while women had worse anxiety scores (p=0.009). Global self-esteem was high (2.7 ± 0.6 for a maximal value of 3), without sex differences. A trend towards a negative correlation between self-esteem and facial scores was observed (rs= -0.559, p=0.074), indicating a low psychological impact.
conclusionIn controlled acromegaly, QoL is relatively preserved in both genders, although men have better anxiety scores. Facial changes have a weak but persistent negative impact on psychological status, with greater intensity observed in women.
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