Evidence map›Paper›PMID 40214482›Full record

ArticleCells2025

Immunopathological Dysregulation in Acute Myeloid Leukemia: The Impact of T-bet, RORγt, and FOXP3 on Disease Dynamics.

Amira M Mohamed Mohy El-Din, Buthayna Ahmad AlShaarawy, Eman Zaghloul Kandeel, Dalia Mahmoud AlDewi, Lobna Abdel Azeem Refaat, Borros Arneth, Hussein Sabit

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amira M Mohamed Mohy El-DinClinical and Chemical Pathology Department, Faculty of Medicine, Misr University for Science and Technology, Giza P.O. Box 77, Egypt.
Buthayna Ahmad AlShaarawyClinical and Chemical Pathology Department, Girls Faculty of Medicine, Al-Azhar University, Cairo 11651, Egypt.
Eman Zaghloul KandeelClinical and Chemical Pathology Department, National Cancer Institute, Cairo University, Giza 12613, Egypt.
Dalia Mahmoud AlDewiClinical and Chemical Pathology Department, Girls Faculty of Medicine, Al-Azhar University, Cairo 11651, Egypt.ORCID 0000-0003-1355-1365
Lobna Abdel Azeem RefaatClinical and Chemical Pathology Department, National Cancer Institute, Cairo University, Giza 12613, Egypt.
Borros ArnethInstitute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Hospital of the Universities of Giessen and Marburg (UKGM), Philipps University Marburg, Baldingerstr 1, 35043 Marburg, Germany.ORCID 0000-0002-9793-0970
Hussein SabitDepartment of Medical Biotechnology, College of Biotechnology, Misr University for Science and Technology, Giza P.O. Box 77, Egypt.ORCID 0000-0001-9021-8334

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The etiology of acute myeloid leukemia (AML) is complex, including genetic and environmental abnormalities. The immune system anomalies play an essential role in the process of leukemogenesis. However, the immunopathological factors, including abnormal T helper (Th) subsets, contributing to the initiation and progression of this neoplasm, require further investigation. Considering the previously mentioned data, we decided to study the expression pattern of transcription factors T-bet, Foxp3, and ROR

Indexed as

Forkhead Transcription FactorsLeukemia, Myeloid, AcuteNuclear Receptor Subfamily 1, Group F, Member 3T-Box Domain ProteinsAdolescentAdultAgedFemaleHumansMaleMiddle AgedT-bet Transcription FactorYoung AdultForkhead Transcription FactorsFOXP3 protein, humanNuclear Receptor Subfamily 1, Group F, Member 3RORC protein, humanT-bet Transcription FactorT-Box Domain Proteinsacute myeloid leukemiaflowcytometrypatternsT helpertranscription factors

Identifiers

PMID40214482
PMCPMC11988856

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.