ArticleCells2025
The Role of Chemotactic Cytokines in Tick-Borne Encephalitis.
Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Evaluation of CXCL12 Diagnostic Performance in Tick-Borne Encephalitis and Other Central Nervous System Infections.International journal of molecular sciences · 2026Article
- The first outbreak of neuroinvasive West Nile virus infection in Istanbul area within 2019.BMC infectious diseases · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
In tick-borne encephalitis (TBE), the central nervous system (CNS) is infiltrated by a mixed leukocyte population contributing both to the infection control and the immune-mediated pathology. To elucidate the roles of chemotactic cytokines in this process, we measured concentrations of 25 cytokines in serum and cerebrospinal fluid (CSF) simultaneously with total CSF leukocyte count (pleocytosis) and leukocyte subpopulation counts in 103 TBE patients. We created models describing the dependence of pleocytosis and clinical severity on cytokine concentrations. Ten polymorphisms in genes for cytokines or their receptors were studied with rtPCR in patients' DNA samples. The strongest chemotactic gradients towards CSF were created by CXCL1, IL-8, CXCL10, CCL2, CCL3, CCL4, CCL7, CCL8, CCL19 and CCL20. Neutrophil counts in CSF correlated with concentrations of CXCL1 and IL-8 and lymphocyte counts with IL-16, CCL19, CCL20, CCL4, CXCL12, and CXCL13. The milder disease is associated with CCL11, CCL19, CXCL10 and CXCL13,-while the more severe with CXCL1 and CCL20. The polymorphisms in the genes
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.