Evidence map›Paper›PMID 40214406›Full record

ArticleACS biomaterials science & engineering2025

TGFβ1 and RGD Cooperatively Regulate SMAD2/3-Mediated Oncogenic Effects in Prostate Cancer Cells in Bio-Orthogonally Constructed Hydrogels.

Mugdha Pol, Hanyuan Gao, Joseph M Fox, Xinqiao Jia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mugdha PolDepartment of Biological Sciences, University of Delaware, Newark, Delaware 19716, United States.
Hanyuan GaoDepartment of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716, United States.ORCID 0009-0006-3096-8460
Joseph M FoxDepartment of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0002-8258-1640
Xinqiao JiaDepartment of Biological Sciences, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0002-3564-5576

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Shawn W Polson · 2012 to 2026
$67.2M
A Hydrogel-Based Cellular Model of the Human Vocal FoldR01DC014461 · NIDCD · UNIVERSITY OF DELAWARE · PI Xinqiao Jia · 2016 to 2026
$6.2M
Research Supplements to Promote Diversity in Health-Related Research (Admin Supp)R01DE029655 · NIDCR · UNIVERSITY OF DELAWARE · PI Xinqiao Jia · 2021 to 2026
$2.8M
Data Management and Storage System for Shared Resource FacilitiesS10OD028725 · OD · UNIVERSITY OF DELAWARE · PI POLSON, SHAWN W · 2021 to 2021
$600k
NIDCD NIH HHS R01 DC014461NIDCR NIH HHS R01 DE029655NIGMS NIH HHS P20 GM103446NIH HHS S10 OD028725
6 · The paper itself

Abstract

To recapitulate prostate cancer metastasis, DU145 cells were cultured in a hyaluronic acid-based, bio-orthogonally constructed, protease-degradable hydrogels. In the presence of a covalently conjugated integrin-binding peptide (G

Indexed as

HydrogelsOligopeptidesProstatic NeoplasmsSmad2 ProteinSmad3 ProteinTransforming Growth Factor beta1Cell Line, TumorEpithelial-Mesenchymal TransitionHumansMaleSignal Transductionarginyl-glycyl-aspartic acidHydrogelsOligopeptidesSmad2 ProteinSMAD2 protein, humanSmad3 ProteinSMAD3 protein, humanTGFB1 protein, humanTransforming Growth Factor beta1epithelial-to-mesenchymal transitionhydrogelsprostate cancerRGDTGFβ1

Identifiers

PMID40214406
PMCPMC12700150

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.