Evidence map›Paper›PMID 40214258›Full record

ArticlemSphere2025

Toward a deeper understanding of dengue: novel method for quantification and isolation of envelope protein epitope-specific antibodies.

Sokchea Lay, Candice Bohaud, Sopheak Sorn, Sreymom Ken, Felix A Rey, Kevin K Ariën, Sowath Ly, Veasna Duong, Giovanna Barba-Spaeth, Heidi Auerswald and 1 more

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sokchea LayImmunology Unit, Institut Pasteur du Cambodge, Pasteur Network, Phnom Penh, Cambodia.
Candice BohaudImmunology Unit, Institut Pasteur du Cambodge, Pasteur Network, Phnom Penh, Cambodia.
Sopheak SornEpidemiology and Public Health Unit, Institut Pasteur du Cambodge, Pasteur Network, Phnom Penh, Cambodia.
Sreymom KenVirology Unit, Institut Pasteur du Cambodge, Pasteur Network, Phnom Penh, Cambodia.
Felix A ReyUnité de Virologie Structurale, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France.ORCID 0000-0002-9953-7988
Kevin K AriënVirology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Sowath LyEpidemiology and Public Health Unit, Institut Pasteur du Cambodge, Pasteur Network, Phnom Penh, Cambodia.
Veasna DuongVirology Unit, Institut Pasteur du Cambodge, Pasteur Network, Phnom Penh, Cambodia.ORCID 0000-0003-0353-1678
Giovanna Barba-Spaeth *Unité de Virologie Structurale, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France.ORCID 0000-0003-2069-9501
Heidi Auerswald *Virology Unit, Institut Pasteur du Cambodge, Pasteur Network, Phnom Penh, Cambodia.ORCID 0000-0002-4717-7618
Tineke Cantaert *Immunology Unit, Institut Pasteur du Cambodge, Pasteur Network, Phnom Penh, Cambodia.ORCID 0000-0002-8911-1502

Funding

Inter-regional study of transmission, adaptation and pathogenesis of viruses with pandemic potential in Southeast Asia and West/Central AfricaU01AI151758 · NIAID · INSTITUT PASTEUR · PI SAKUNTABHAI, ANAVAJ, SIMON-LORIERE, ETIENNE · 2020 to 2024
$6.7M
NIAID NIH HHS U01 AI151758
6 · The paper itself

Abstract

The dengue viruses (DENV) envelope (E) protein is the main target of the antibody (Ab) response. Abs target different epitopes on the E-protein, including sE-dimer, E domain III (EDIII), and fusion loop (FL). Anti-EDIII Abs are mainly serotype-specific, whereas anti-FL Abs can induce antibody-dependent enhancement (ADE)

Indexed as

Antibodies, ViralDengueDengue VirusEpitopesViral Envelope ProteinsAnimalsAntibodies, MonoclonalAntibodies, NeutralizingHumansImmunoassayImmunoglobulin GAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralEpitopesImmunoglobulin GViral Envelope Proteinsantibody-dependent enhancementantibody response to denguedengue virusflavivirus anti-envelope antibodies

Identifiers

PMID40214258
PMCPMC12108060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.