Evidence map›Paper›PMID 40214248›Full record

ReviewmBio2025

mGem: Sepsis and antimicrobial resistance in the context of advanced HIV disease.

Rachel M Wake, Nelesh P Govender

Abstract readReview
In one paragraph

Review in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rachel M WakeWits Mycology Division, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.ORCID 0000-0003-3193-4888
Nelesh P GovenderWits Mycology Division, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.ORCID 0000-0001-7869-9462

Funding

Bill and Melinda Gates Foundation INV077442National Institute for Health and Care Research NIHR 134342National Institute for Health and Care Research NIHR 303140
6 · The paper itself

Abstract

Sepsis triggered by bloodstream infections (BSI) is a significant driver of HIV-related mortality, particularly among in-patients with advanced HIV disease (AHD). Currently, the incidence, etiology, and outcomes of BSI in this population are poorly defined. We review the existing evidence, which shows an increased risk of BSI, particularly with antimicrobial-resistant (AMR) organisms, and higher BSI-associated mortality in patients with AHD. Causative bacterial and fungal pathogens are often unknown, but when identified, limited data show etiology has shifted probably owing to increasing coverage of antiretroviral treatment, antimicrobial prophylaxis, and rising global AMR trends. Further research is crucial to design and refine interventions before, during, and after hospital admission to reduce sepsis-related mortality in patients with AHD.

Indexed as

Drug Resistance, BacterialHIV InfectionsSepsisAnti-Bacterial AgentsBacteriaHumansAnti-Bacterial AgentsAIDSantimicrobial resistancebloodstream infectionshuman immunodeficiency virussepsis

Identifiers

PMID40214248
PMCPMC12077103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.