Evidence map›Paper›PMID 40214223›Full record

ArticlemBio2025

A diverse set of solubilized natural fibers drives structure-dependent metabolism and modulation of the human gut microbiota.

Maria X Maldonado-Gomez, Katharine M Ng, Riley A Drexler, Alexandria M S Conner, Cory G Vierra, Nithya Krishnakumar, Hannah M Gerber, Zachary R Taylor, Jenna L Treon, Megan Ellis and 7 more

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Maria X Maldonado-Gomez *One Bio Inc., Sacramento, California, USA.ORCID 0000-0001-5403-1740
Katharine M Ng *One Bio Inc., Sacramento, California, USA.ORCID 0000-0003-3494-5697
Riley A DrexlerOne Bio Inc., Sacramento, California, USA.
Alexandria M S ConnerOne Bio Inc., Sacramento, California, USA.
Cory G VierraOne Bio Inc., Sacramento, California, USA.
Nithya KrishnakumarOne Bio Inc., Sacramento, California, USA.
Hannah M GerberOne Bio Inc., Sacramento, California, USA.ORCID 0009-0006-5278-3686
Zachary R TaylorOne Bio Inc., Sacramento, California, USA.ORCID 0009-0009-7075-6640
Jenna L TreonOne Bio Inc., Sacramento, California, USA.
Megan EllisOne Bio Inc., Sacramento, California, USA.
Jada K A GarciaOne Bio Inc., Sacramento, California, USA.ORCID 0009-0000-0109-4721
James P CerneyOne Bio Inc., Sacramento, California, USA.ORCID 0009-0008-1312-1203
David G ChapinOne Bio Inc., Sacramento, California, USA.
Robnet T KernsOne Bio Inc., Sacramento, California, USA.
Angela M MarcobalOne Bio Inc., Sacramento, California, USA.
Steven M WatkinsOne Bio Inc., Sacramento, California, USA.ORCID 0000-0002-3738-3768
Matthew J AmicucciOne Bio Inc., Sacramento, California, USA.ORCID 0000-0002-1392-9252

Funding

One Bio Inc
6 · The paper itself

Abstract

Growing evidence suggests that inadequate dietary fiber intake, termed the "fiber gap," is linked to disease states through disruption of the gut microbiota. Despite this, our understanding of how various fiber structures influence the microbiota and health is limited by the lack of diverse commercially available fibers. Studies have primarily focused on a limited range of fibers, rather than the diverse array of fibers representative of those commonly found in our diets. In this study, we aimed to investigate how naturally derived fibers impact the human microbiota and their metabolic products. We performed a comprehensive structural characterization and functional evaluation of a unique and highly diverse set of new, highly soluble fibers with varied monosaccharide compositions, glycosidic linkages, and polymer lengths. Using an

Indexed as

BacteriaDietary FiberGastrointestinal MicrobiomeFecesFemaleHumansMaleMetabolomeMetabolomicsDietary Fibercarbohydratedietary fibergut microbiotahuman microbiotaoligosaccharidesshort-chain fatty acids

Identifiers

PMID40214223
PMCPMC12077125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.