Evidence map›Paper›PMID 40214191›Full record

ReviewClinical and translational science2025

AI-Driven Applications in Clinical Pharmacology and Translational Science: Insights From the ASCPT 2024 AI Preconference.

Mohamed H Shahin, Prashant Desai, Nadia Terranova, Yuanfang Guan, Tomáš Helikar, Sebastian Lobentanzer, Qi Liu, James Lu, Subha Madhavan, Gary Mo and 6 more

Abstract readReview
In one paragraph

Review in Clinical and translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mohamed H ShahinPfizer Research & Development, Groton, Connecticut, USA.
Prashant DesaiDrug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California, USA.ORCID 0000-0002-2493-8218
Nadia TerranovaQuantitative Pharmacology, Ares Trading S.A. (an Affiliate of Merck KGaA, Darmstadt, Germany), Lausanne, Switzerland.ORCID 0000-0002-0033-3695
Yuanfang GuanGilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-8275-2852
Tomáš HelikarDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.ORCID 0000-0003-3653-1906
Sebastian LobentanzerFaculty of Medicine and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg University, Heidelberg, Germany.ORCID 0000-0003-3399-6695
Qi LiuOffice of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.ORCID 0000-0002-4053-4213
James LuModeling & Simulation/Clinical Pharmacology, Genentech Research & Early Development, South San Francisco, California, USA.ORCID 0000-0002-9687-5607
Subha MadhavanPfizer R&D, New York, New York, USA.ORCID 0000-0001-7617-3547
Gary MoPfizer Research & Development, Groton, Connecticut, USA.ORCID 0000-0001-7805-5077
Flora T MusuambaFederal Agency for Medicines and Health Products, Brussels, Belgium.ORCID 0000-0001-8276-8870
Jagdeep T PodichettyQuantitative Medicine, Critical Path Institute, Tucson, Arizona, USA.ORCID 0009-0001-3922-3549
Jie ShenClinical Sciences, AbbVie, North Chicago, Illinois, USA.
Lei XieDepartment of Computer Science, Hunter College, The City University of New York, New York, New York, USA.
Mathew WiensMetrum Research Group, Boston, Massachusetts, USA.
Cynthia J MusantePfizer Research & Development, Cambridge, Massachusetts, USA.

Funding

Software for collaborative construction, simulation, and analysis of mechanistic computational models of biological systemsR35GM119770 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI Tomas Helikar · 2016 to 2026
$4.4M
NIGMS NIH HHS R35 GM119770
6 · The paper itself

Abstract

Artificial intelligence (AI) is driving innovation in clinical pharmacology and translational science with tools to advance drug development, clinical trials, and patient care. This review summarizes the key takeaways from the AI preconference at the American Society for Clinical Pharmacology and Therapeutics (ASCPT) 2024 Annual Meeting in Colorado Springs, where experts from academia, industry, and regulatory bodies discussed how AI is streamlining drug discovery, dosing strategies, outcome assessment, and patient care. The theme of the preconference was centered around how AI can empower clinical pharmacologists and translational researchers to make informed decisions and translate research findings into practice. The preconference also looked at the impact of large language models in biomedical research and how these tools are democratizing data analysis and empowering researchers. The application of explainable AI in predicting drug efficacy and safety, and the ethical considerations that should be applied when integrating AI into clinical and biomedical research were also touched upon. By sharing these diverse perspectives and real-world examples, this review shows how AI can be used in clinical pharmacology and translational science to bring efficiency and accelerate drug discovery and development to address patients' unmet clinical needs.

Indexed as

Artificial IntelligencePharmacology, ClinicalTranslational Research, BiomedicalTranslational Science, BiomedicalClinical Trials as TopicDrug DevelopmentDrug DiscoveryHumansartificial intelligenceexplainable machine learninglarge language modelsmachine learning

Identifiers

PMID40214191
PMCPMC11987044

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.