Evidence map›Paper›PMID 40214131›Full record

ArticleJournal of global health2025

Comparison of excess deaths and laboratory-confirmed COVID-19 deaths during a large Omicron epidemic in 2022 in Hong Kong.

Hualei Xin, Alexandra H T Law, Justin K Cheung, Yun Lin, Peng Wu, Zhongjie Li, Benjamin J Cowling, Weizhong Yang, Jessica Y Wong

Abstract readComparative Study
In one paragraph

Article in Journal of global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hualei XinSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Alexandra H T LawWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Justin K CheungWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Yun LinWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Peng WuWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Zhongjie LiSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Benjamin J CowlingWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Weizhong YangSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Jessica Y WongWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Using an elimination strategy, Hong Kong was able to minimise COVID-19 mortality in 2020 and 2021, but a large epidemic caused by the Omicron variant occurred in 2022. We aimed to estimate the overall, age-, sex-, epidemic period- and cause-specific excess mortality in 2022 in Hong Kong and compare excess mortality to laboratory-confirmed COVID-19 mortality. Methods: We used negative binomial regression analysis to model time series of weekly all-cause and cause-specific deaths from 2010 to 2021 to predict the weekly number of deaths in 2022 against counterfactual baselines projected from the trends in the absence of a pandemic. The estimated excess deaths were compared with laboratory-confirmed COVID-19 deaths overall and by age and epidemic period. Results: We estimated that there were 13 500 (95% confidence interval (CI) = 13 400, 13 600) excess deaths in 2022, which was slightly higher than the 12 228 deaths recorded with laboratory-confirmed COVID-19, with the majority of the excess deaths and laboratory-confirmed deaths occurring among older adults. The increased number of excess deaths over laboratory-confirmed COVID-19 deaths was most substantial from February to April 2022 (a difference of 847 deaths), when the most prominent Omicron wave peaked. Most of the excess deaths (78%) were from respiratory causes, while 10% were from cardiovascular causes. A slight reduction in malignant neoplasm mortality was identified among older adults in 2022. Conclusions: A substantial increase in population mortality was identified in 2022 in Hong Kong, slightly larger than the laboratory-confirmed COVID-19 deaths. Deaths from COVID-19 may have displaced some deaths that would otherwise have occurred due to other causes.

Indexed as

COVID-19AdolescentAdultAgedAged, 80 and overCause of DeathChildChild, PreschoolFemaleHong KongHumansInfantInfant, NewbornMaleMiddle AgedSARS-CoV-2

Identifiers

PMID40214131
PMCPMC11987577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.