ArticleJournal of veterinary internal medicine
Prevalence of a Novel Immunogenic Feline Erythrocyte Antigen (FEA 6) and Expression Patterns Between FEAs.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
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Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
backgroundAfter the identification of five novel feline erythrocyte antigens (FEAs) and evidence establishing FEA 1's immunogenicity, attempts to sensitize a cat to FEA 4 unexpectedly resulted in the production of alloantibodies directed against an unknown antigen, named FEA 6.
objectivesTo estimate the prevalence of FEA 6 as a presumably new antigen, identify corresponding naturally occurring alloantibodies (NOAb), and investigate the associations between known FEAs. ANIMALS: Two hundread and seven cats.
methodsProspective blood typing for FEAs 1-6 was conducted in Type A cats (n = 193), followed by serial crossmatching in groups of 3-7 cats to detect NOAb and identify their target FEA. Agreement between FEA 6 blood typing and other FEAs was assessed. Associations between FEAs were evaluated to identify expression patterns.
resultsAmong 193 Type A cats, 67% were FEA 6-positive. Agreement analyses were supportive of FEA 6 being distinct from FEAs 1-5. NOAb were detected in 11 cats (5.7%), none of which were anti-FEA 6. Only FEA 1-negative status was significantly associated with the presence of NOAb (OR = 6.6, 95% CI, 1.9-23.1; p < 0.001). Significant associations were observed between the expressions of FEAs 1 and 4 (χ CONCLUSIONS AND CLINICAL IMPORTANCE: The immunogenicity and prevalence of the newly discovered FEA 6 raise concerns regarding its clinical relevance and role in posttransfusion sensitization. FEA 1/FEA 4 and FEA 3/FEA 5 pairs might belong to distinct antigenic systems.
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