Evidence map›Paper›PMID 40213960›Full record

ArticleCancer reports (Hoboken, N.J.)2025

Perceptions and Attitudes Toward Utilizing a Non-Invasive Biomarker for Colorectal Cancer Screening: A Qualitative Study.

Choi Ying Chu, Junjie Huang, Jamie Jie Mei Liew, Apurva Sawhney, Xianjing Liu, Chaoying Zhong, Jianli Lin, Junjie Hang, Claire Chenwen Zhong, Jinqiu Yuan and 1 more

Abstract read
In one paragraph

Article in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Choi Ying ChuThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Junjie HuangThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0003-2382-4443
Jamie Jie Mei LiewThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Apurva SawhneyThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Xianjing LiuDepartment of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Chaoying ZhongDepartment of Electrical Engineering and Automation, Guangdong Ocean University, Zhanjiang, Guangdong, China.
Jianli LinPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Junjie HangCancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, Guangdong, China.ORCID 0000-0003-1297-5764
Claire Chenwen ZhongThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Jinqiu YuanClinical Research Center, Big Data Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Martin C S WongThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Funding

SunRise Diagnostic Centre Limited
6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) screening, effective for early detection of CRC, was recently implemented by the Hong Kong government using the quantitative Fecal Immunochemical Test (FIT). However, consistently low participation rates and heavy reliance on colonoscopy for CRC screening has created a substantial burden on the healthcare system.

aimsThis study examined the feasibility, acceptability, and satisfaction of utilizing the novel non-invasive biomarker test Colotect for early detection of CRC. METHODS AND

resultsIn-depth, qualitative telephone interviews were conducted with 16 participants (≥ 50 years old) who were eligible for the government CRC screening program. Participants were recruited via community health centres in Hong Kong between July and August 2022. The Consolidated Framework for Implementation Research (CFIR) was used to prepare the interview guide exploring the perceptions, attitudes, and barriers to using Colotect. The data collected was categorized into eight themes corresponding to the CFIR interventional characteristics domain, including intervention sources, evidence strength & quality, relative advantage, adaptability, complexity, design quality and packaging, and cost.

conclusionOverall, participants reflected positive attitudes and perceptions toward Colotect use, along with identifying difficulties associated with its use. Modifications to test kits were proposed corresponding to the issues identified. In summary, this study demonstrated the feasibility and acceptability of using Colotect in CRC screening program. Future studies should examine the applicability, acceptability, efficiency, and cost-effectiveness of the test in real-world settings.

Indexed as

Biomarkers, TumorColorectal NeoplasmsEarly Detection of CancerHealth Knowledge, Attitudes, PracticePatient Acceptance of Health CareAgedColonoscopyFeasibility StudiesFecesFemaleHong KongHumansMaleMiddle AgedOccult BloodQualitative ResearchBiomarkers, Tumorbiomarkercolorectal cancerDNA testperceptionscreening

Identifiers

PMID40213960
PMCPMC11986842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.