Evidence map›Paper›PMID 40213827›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Reversible High-Affinity Binding of Coagulation Factor Xa to Zeolites Induces Accelerated Blood Coagulation.

Chaojie Shi, Meijuan He, Hao Chen, Xuefei Wei, Liping Xiao, Xiaoqiang Shang, Yifeng Shi, Qi Wang, Lisha Yu, Jie Fan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chaojie ShiKey Lab of Applied Chemistry of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, China.
Meijuan HeKey Lab of Applied Chemistry of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, China.
Hao ChenKey Lab of Applied Chemistry of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, China.
Xuefei WeiKey Lab of Applied Chemistry of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, China.
Liping XiaoKey Lab of Applied Chemistry of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, China.
Xiaoqiang ShangCollege of Chemistry and Chemical Engineering, Nanchang University, Nanchang, Jiangxi, 330031, China.
Yifeng ShiKey Lab of Applied Chemistry of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, China.
Qi WangKey Lab of Applied Chemistry of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, China.
Lisha YuKey Lab of Applied Chemistry of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, China.
Jie FanKey Lab of Applied Chemistry of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, China.ORCID https://orcid.org/0000-0002-8380-6338

Funding

National Natural Science Foundation of China 82202483National Natural Science Foundation of China 91845203National Natural Science Foundation of China 92045301
6 · The paper itself

Abstract

Zeolite is recognized as an essential hemostatic material for controlling massive bleeding. Elucidating the procoagulant mechanism of zeolite is critically important, as it will facilitate the rational design of more effective zeolite-based hemostatic materials. In this study, it is discovered an extremely strong, calcium-dependent interaction between coagulation factor Xa (FXa) and zeolite-termed target-specific biorecognition-that mimics the FXa/factor Va (FXa/FVa) interface formed during the natural coagulation cascade. This interaction alters the prothrombin activation pathway to a more efficient mechanism, significantly amplifying FXa activity. Notably, the complex structure and FXa activity can be reversibly modulated through Na

Indexed as

Blood CoagulationFactor XaZeolitesHumansProtein BindingFactor XaZeolitesbiorecognitioncoagulationfactor Xaproteasezeolite

Identifiers

PMID40213827
PMCPMC12165020

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.