ReviewCureus2025
Epigenetic Mechanisms in the Transfer of Metabolic Disorders: A Comprehensive Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Understanding the mechanisms underlying obesity induced tumorigenesis: therapeutic perspectives to manage dysregulated lipid metabolism.Discover oncology · 2026Review
- Association of Triglyceride-Glucose-Frailty Index with Cardiovascular Disease and All-Cause Mortality Incidence in Individuals with Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: A Nationwide Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Nutrient-Sensitive Epigenetic Modifiers as Candidate Biomarkers of Metabolic Dysfunction in Obesity: A Nutrigenomic Review.International journal of molecular sciences · 2026Review
- Article
- Review
- Therapeutic potential of HDAC6 inhibitor Tubastatin A in health and diseases: current perspective and future directions.Military Medical Research · 2026Review
- PANoptosis in diabetic retinopathy: immunological insights into mechanisms and translational therapies.Frontiers in immunology · 2026Review
- From Molecular Insights to Clinical Management of Gestational Diabetes Mellitus-A Narrative Review.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic modifications, including deoxyribonucleic acid (DNA) methylation, histone modifications, and non-coding ribonucleic acid (ncRNAs), regulate gene expression without altering the DNA sequence and play pivotal roles in the pathogenesis of metabolic disorders (MDs), such as diabetes, obesity, and cardiovascular diseases. This review aims to consolidate the current knowledge on the epigenetic mechanisms underlying MDs, emphasizing histone modifications and ncRNAs. A comprehensive literature search was conducted using the PubMed, Scopus, and Web of Science databases. Studies published between 2000 and 2024 (a few foundational and historical articles were also added) were screened using search terms such as "epigenetics AND metabolic disorders," "DNA methylation AND diabetes," "histone modifications AND obesity," and "non-coding RNA AND cardiovascular diseases." Relevant translational and clinical studies were reviewed to synthesize the existing evidence on the epigenetic regulation of metabolic diseases. Histone modifications, including acetylation, methylation, phosphorylation, and ubiquitination, contribute to metabolic dysregulation by modulating chromatin accessibility and gene transcription. Additionally, ncRNAs, such as microRNAs, long ncRNAs, and circular RNAs, influence metabolic pathways by post-transcriptionally regulating key genes involved in insulin resistance, lipid metabolism, and inflammation. Emerging research highlights the potential of epigenetic biomarkers for early disease detection and prognosis, as well as the therapeutic potential of epigenetic modulators, including histone deacetylase inhibitors and DNA methylation-targeting agents. Despite promising advances, challenges remain in translating epigenetic findings into clinical practice because of inter-individual variability and the complex interplay between genetics and environmental factors. Future research should focus on large-scale, multicenter studies to validate epigenetic biomarkers and develop personalized epigenetic interventions for MDs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.