Vitamin D supplementation at low (600 IU/day) or higher dose (3,750 IU/day) does not improve insulin resistance markers at one year: A randomized controlled trial.

Nancy Safwan, Christos S Mantzoros, Maya Rahme, Rafic Baddoura, Georges Halaby, Ghada El-Hajj Fuleihan

Registry-linked trialAbstract read

In one paragraph

Article in Metabolism open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01315366 (Phase III Study on the Effect of Vitamin D Supplementation on Indices of Mineral and Musculoskeletal Metabolism and on Parameters of Glucose and Fuel Metabolism in Elderly Subjects), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01315366 phase3completednot on this map

Phase III Study on the Effect of Vitamin D Supplementation on Indices of Mineral and Musculoskeletal Metabolism and on Parameters of Glucose and Fuel Metabolism in Elderly Subjects

TypeinterventionalSponsorAmerican University of Beirut Medical CenterRan2011 to 2015Enrolled257ConditionsHypovitaminosis D, Insulin Resistance, Obesity, OsteoporosisArmsEuro D and Ci-CalD, Euro D, Ci-CalD

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nancy SafwanScholars in Health Research Program, Department of Internal Medicine, American University of Beirut, Beirut, 11-0236, Lebanon.

Christos S MantzorosDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Boston VA Healthcare System and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

Maya RahmeDepartment of Internal Medicine, Division of Endocrinology, Calcium Metabolism and Osteoporosis Program, WHO CC for Metabolic Bone Disorders, American University of Beirut Medical Center, Beirut, 11-0236, Lebanon.

Rafic BaddouraDepartment of Internal Medicine, Division of Rheumatology, Hôtel-Dieu de France, Beirut, Lebanon.

Georges HalabyDepartment of Internal Medicine, Division of Endocrinology, Hôtel-Dieu de France, Beirut, Lebanon.

Ghada El-Hajj FuleihanScholars in Health Research Program, Department of Internal Medicine, American University of Beirut, Beirut, 11-0236, Lebanon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: To compare the performance of newer insulin resistance (IR) indices, triglyceride glucose index (TyG) and metabolic score for IR (METS-IR), with previous markers HOMA-IR and McAuley-IR, and assess the impact of one-year of vitamin D supplementation, at two doses, on these indices in overweight, elderly individuals. Methods: Exploratory analyses from a double-blind, multicenter randomized controlled trial involved overweight elderly participants with baseline serum 25-hydroxyvitamin D [25(OH)D] levels of 10-30 ng/ml (clinicaltrial.gov: NCT01315366). Participants received 1000 mg calcium citrate/day and vitamin D supplementation at a low-dose of 600 IU/day, or high-dose of 3750 IU/day. Results: 221 participants received low or high-dose vitamin D supplementation. Mean age was 71 ± 5 years, BMI 30 ± 4 kg/m Conclusions: Vitamin D supplementation at 3750 IU/d over one-year did not improve IR markers, including TyG and METS-IR.

Indexed as

Insulin resistanceMetabolic score for insulin resistanceMETS-IRRandomized controlled trialTriglyceride glucose indexTyGVitamin D

Identifiers

PMID40213648

DOI10.1016/j.metop.2025.100357

PMCPMC11984570

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

NCT01315366ClinicalTrials.gov

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.