ReviewFrontiers in bioengineering and biotechnology2025
Insulin-like growth factor-1 (IGF-1) empowering tendon regenerative therapies.
Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Cryopreserved umbilical allograft (equicenta® CTM) improves clinical outcomes compared with clinician-selected standard of care in performance horses: a pragmatic prospective controlled trial.Frontiers in veterinary science · 2026Trial
- Germ cells are hidden contributors to sex differences in vertebrate lifespan.The Journal of reproduction and development · 2026Review
- An intelligent nano-engineered PLGA@IGF-1 hydrogel for programmed immune modulation and tendon regeneration via IGF-1R/AKT signaling.Journal of nanobiotechnology · 2026Article
- Tetranectin is significantly elevated in the synovial fluid of patients with full-thickness rotator cuff tears.Scientific reports · 2026Article
- Growth Performance and Economic Efficiency of SASSO-C44 Broilers Fed on Diets Containing Varying Levels of Dried Blood-Rumen Mixture as a Substitute for Roasted Soybean Meal.Food science & nutrition · 2026Article
- Maternal supplementation with rumen-protected arginine reshapes the ileal microbiome and enhances neonatal lamb growth.Animal microbiome · 2026Article
- Therapeutically Induced Modulation of Collagen I-to-III Ratio Three Weeks After Rabbit Achilles Tendon Full Transection.Biology · 2026Article
- Advances in Achilles Tendon Tissue Engineering: Integrating Cells, Scaffolds, and Mechanical Loading for Functional Regeneration.Bioengineering (Basel, Switzerland) · 2025Review
- Spinal Cord Injury 2.0: Bridging the Gap Between Neurobiology, Technology, and Hope in the Era of Precision Medicine.Stem cell reviews and reports · 2025Review
- Contribution of insulin‑like growth factor‑1 to tendon repair (Review).International journal of molecular medicine · 2025Review
- Single-cell sequencing reveals cellular heterogeneity and molecular mechanisms in tendon and enthesis injury repair.Frontiers in physiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tendon injury is one of the most common musculoskeletal disorders that severely affect patients' daily lives. Unfortunately, naturally healed tendons exhibit poor quality, as they have very limited regenerative ability. Recently, therapeutic strategies involving the administration of growth factors have been advocated to enhance tendon regenerative healing. Growth factors are peptide-signaling molecules that elicit biological functions such as cell proliferation, migration, and differentiation by acting through a complex organization of cell surface receptors and activating intracellular signaling pathways. Insulin-like growth factor-1(IGF-1) represents one such factor that has shown promising effects for enhancing tendon regenerative healing
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.