Evidence map›Paper›PMID 40213630›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

Humanized Na

Dillon S McDevitt, Joshua D Vardigan, Xiaoping Zhou, Thomas W Rosahl, Heather Zhou, Eric A Price, Michelle K Clements, Yuxing Li, Nissi Varghese, Alicja Krasowska-Zoladek and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Discovery of MK-5661, a Once-Daily Oral NaACS medicinal chemistry letters · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Dillon S McDevittDiscovery Neuroscience, Merck & Co., Inc., Rahway, NJ, USA.
Joshua D VardiganDiscovery Neuroscience, Merck & Co., Inc., Rahway, NJ, USA.
Xiaoping ZhouDiscovery Neuroscience, Merck & Co., Inc., Rahway, NJ, USA.
Thomas W RosahlQuantitative Biosciences, Merck & Co., Inc., Rahway, NJ, USA.
Heather ZhouQuantitative Biosciences, Merck & Co., Inc., Rahway, NJ, USA.
Eric A PriceDiscovery Neuroscience, Merck & Co., Inc., Rahway, NJ, USA.
Michelle K ClementsDiscovery Neuroscience, Merck & Co., Inc., Rahway, NJ, USA.
Yuxing LiDiscovery Neuroscience, Merck & Co., Inc., Rahway, NJ, USA.
Nissi VargheseDiscovery Neuroscience, Merck & Co., Inc., Rahway, NJ, USA.
Alicja Krasowska-ZoladekDiscovery Neuroscience, Merck & Co., Inc., Rahway, NJ, USA.
Shawn J StachelDiscovery Chemistry, Merck & Co., Inc., Rahway, NJ, USA.
Michael J BreslinDiscovery Chemistry, Merck & Co., Inc., Rahway, NJ, USA.
Christopher S BurgeyDiscovery Chemistry, Merck & Co., Inc., Rahway, NJ, USA.
Richard L KrausDiscovery Neuroscience, Merck & Co., Inc., Rahway, NJ, USA.
Parul S PallDiscovery Neuroscience, Merck & Co., Inc., Rahway, NJ, USA.
Darrell A HenzeDiscovery Neuroscience, Merck & Co., Inc., Rahway, NJ, USA.
Vincent P SantarelliDiscovery Neuroscience, Merck & Co., Inc., Rahway, NJ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Voltage-gated sodium channel isoform 1.8 (Na

Indexed as

Capsaicin nocifensive behaviorComplete Freund’s adjuvantNav1.8Pharmacokinetic pharmacodynamicSpinal nerve ligation

Identifiers

PMID40213630
PMCPMC11984575

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.