ArticleSmall science2021
Functional Nucleic-Acid-Decorated Spherical Nanoparticles: Preparation Strategies and Current Applications in Cancer Therapy.
Article in Small science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Aptamers targeting immune checkpoints for tumor immunotherapy: a comprehensive review.Frontiers in oncology · 2026Review
- The nucleic acid reactions on the nanomaterials surface for biomedicine.Journal of nanobiotechnology · 2025Review
- Ophthalmic Tethered Gold Yarnball-Mediated Retained Drug Delivery for Eye Fundus Disease Treatment.Small science · 2024Article
- Entropy-Mediated Nanoparticle Cellular Uptake.Small science · 2024Article
- Nanomedicine in the Face of Parkinson's Disease: From Drug Delivery Systems to Nanozymes.Cells · 2022Review
- Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach.Molecules (Basel, Switzerland) · 2022Review
- Multidrug Resistance of Cancer Cells and the Vital Role of P-Glycoprotein.Life (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional nucleic acids (FNAs) have drawn widespread attention in the construction of functional nanomaterials for biomedical applications due to their inherent biological functions and sequence programmability, as well as high thermal stability and easy chemical modification. FNA-decorated spherical nanoparticles (FSNPs) are composed of a metal/metal-free spherical core and a radially oriented FNA shell. Attracted by their unique capabilities, such as resistance to nuclease degradation and capability of crossing the blood-brain barrier, FSNPs as smart nanomaterials for cancer therapy are reviewed. The preparation strategies of FSNPs are first summarized, and the applications of responsive linkers in stimuli-responsive drug release are introduced. The FSNPs are categorized into aptamer-, i-motif-, DNAzyme-, antisense oligonucleotide-, and CpG oligodeoxynucleotide-decorated SNPs. Their applications in cancer therapy include tumor-targeting drug delivery and controllable releasing of drugs, overcoming physiological or pathological obstacles such as blood-brain barrier and interstitial transport barriers, as well as a reversal of resistance to chemotherapy and antitumor immune response activation. The remaining challenges and future directions of FSNPs are also discussed and proposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.