ReviewAdvanced biomedical research2025
Role of IGFBP-3 in Human Diseases Relying on Different Cell Signaling Pathways.
Review in Advanced biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Insulin-like growth factor receptor signaling in physiology and disease.Signal transduction and targeted therapy · 2026Review
- IGFBP in tumor immunity: a novel target for cancer immunotherapy.Journal of translational medicine · 2026Review
- Genomics link obesity and type 2 diabetes to Alzheimer's disease to unveil novel biological insights.medRxiv : the preprint server for health sciences · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Insulin growth factor protein 3 (IGFBP-3) is a member of the binding protein family which is known as the main carrier of insulin-like growth factors in human serum. Through the existence of multiple IGFBP-3 binding partners such as insulin growth factors (IGFs), transmembrane receptor 219 (TMEM219) protein, retinoid X receptors (RXRs), and other proteins, in IGF-dependent and IGF-independent cell signaling pathways, IGFBP-3 exerts the various key roles associated with physiological processes such as cell growth prevention and differentiation, apoptosis induction and have several metabolic activities such as regulating blood glucose, lipid metabolism, regulating bone, and chondrocyte growth as well. Moreover, IGFBP-3 plays an important role in the pathophysiology of a variety of human diseases including ischemia, Alzheimer's disease, diabetes mellitus, asthma, and cancer. Therefore, in this current study, we intend to describe the IGFBP-3 role depending on its effect on the pathophysiology of human illnesses.
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Registered trials
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