Evidence map›Paper›PMID 40213589›Full record

ReviewAdvanced biomedical research2025

Microalgae: A Treasure Trove of Anticancer Nutraceuticals and Promising Therapeutic Mechanisms.

Sajjad Masoumi, Maryam Zokaei, Ardavan Ahmadvand, Nogol Ghalamkarpour, Naghmeh Asadimanesh, Armin Azarimatin, Khashayar Fattah, Zahra Payandeh, Masoumeh Rostami, Afsaneh Farjami and 2 more

Abstract readReview
In one paragraph

Review in Advanced biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Anticancer and Antimicrobial Activity ofMolecules (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sajjad MasoumiDepartment of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Maryam ZokaeiDepartment of Veterinary Medicine, Beyza Branch, Islamic Azad University, Beyza, Iran.
Ardavan AhmadvandFaculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Nogol GhalamkarpourDepartment of Clinical Laboratory Sciences, School of Allied Medicine, Lorestan University of Medical Sciences, Iran.
Naghmeh AsadimaneshSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Armin AzarimatinDepartment of Veterinary Medicine, Shabestar Branch, Islamic Azad University, Shabestar, Iran.
Khashayar FattahSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zahra PayandehDepartment Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Masoumeh RostamiDepartment of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Afsaneh FarjamiPharmaceutical and Food Control Department, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Rajan Kumar PandeyDepartment Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Mohsen Nabi-AfjadiDepartment of Biochemistry, Faculty of Biological Sciences, University of Tarbiat Modares, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With cancer remaining a global health concern, the need for new and effective preventive and treatment methods is paramount. Microalgae have emerged as a potential source of anticancer nutraceuticals. Our research indicates that substances produced from microalgae, such as carotenoids, polyunsaturated fatty acids, phycocyanin, and polysaccharides, have shown anticancer effects in both laboratory and human investigations. Carotenoids, including astaxanthin, have shown the ability to hinder the development of tumors and trigger programmed cell death (apoptosis) in several types of cancer cells. Moreover, studies have shown that phycocyanin, a blue pigment present in some species of microalgae, has properties that help reduce inflammation and combat cancer. Potential future research directions include expanding the scope of the study to encompass a diverse range of microalgae species, identifying other compounds with anticancer properties, and investigating the mechanisms by which chemicals derived from microalgae function in the treatment and prevention of cancer. Moreover, it is important to establish scalable and sustainable procedures for the industrial production of compounds derived from microalgae. In conclusion, our evaluation reveals that microalgae have enormous potential as a source of anticancer nutraceuticals, containing a variety of bioactive substances that could eventually lead to the development of novel and effective cancer prevention and treatment methods. To realize the maximum potential of chemicals derived from microalgae, it is necessary to develop a sustainable and environmentally benign industry and to continue research in this area.

Indexed as

Algaeapoptosiscancermechanism of actionmicroalgaenutraceutical

Identifiers

PMID40213589
PMCPMC11981035

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.