Evidence map›Paper›PMID 40213587›Full record

ReviewAdvanced biomedical research2025

A Systematic Review on Important Risk Factors and Possible Involved Mechanisms of Medicinal Plants on Nonalcoholic Fatty Liver Disease.

Amir Reza Rouhi-Boroujeni, Fatemeh Aliakbari, Ehsan Bakhshian-Dehkordi, Lotfolah Afzali, Hojjat Rouhi-Boroujeni

Abstract readReview
In one paragraph

Review in Advanced biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Pharmaceutics · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amir Reza Rouhi-BoroujeniInstitute of Pharmacy, I. M. Sechenov First Moscow State Medical University, Moscow, Russia.
Fatemeh AliakbariCommunity-Oriented Nursing Midwifery Research Center, Shahr-e-Kord University of Medical Sciences, Shahr-e-Kord, Iran.
Ehsan Bakhshian-DehkordiClinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Lotfolah AfzaliClinical Research Development Unit, Ayatollah Kashani Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Hojjat Rouhi-BoroujeniClinical Research Development Unit, Ayatollah Kashani Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is one of the most common diseases in the industrialized world. Hyperlipidemia, obesity, hypertension, and diabetes are known to be major risk factors for NAFLD, and chemical drugs are rarely effective in treating this disease and may cause significant complications. It is believed that medicinal plants with antioxidant properties and several other mechanisms have high preventive and therapeutic effects. This study was conducted with the aim of determining the effective mechanisms of plants on NAFLD and its risk factors. First, efficient plants and disease risk factors were identified; then, by reviewing scientific information sources and 6523 articles, the positive effects of plants on each risk factors were investigated. This information was recorded in checklist 1. Another 1100 articles (a total of 7623 articles) were systematically reviewed, and the mechanisms of the selected factories regarding the above risk factors were recorded in Checklist No. 2. Plants, their scientific names, family names, the used parts, and their possible mechanisms were identified in the case of 43 effective plants, and their molecular and genetic mechanisms were recorded. According to the results, 33 plants affect all four risk factors, eight of which affect three factors and two affect only two factors. In general, most of the mechanisms were in the prevention and treatment of NAFLD. Identification of plants and their effective mechanisms in NAFLD will reduce the incidence of this disease and produce new potent and selective herbal medicines that inhibit each of the risk factors.

Indexed as

Herbal plantshypolipidemicnonalcoholic fatty liver diseaseobesity

Identifiers

PMID40213587
PMCPMC11981046

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.