Evidence map›Paper›PMID 40213579›Full record

ArticleSmall science2024

Unveiling the Potential of Single-Cell Encapsulation in Biomedical Applications: Current Advances and Future Perspectives.

Manuel Pires-Santos, Sara Nadine, João F Mano

Abstract read
In one paragraph

Article in Small science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Metal-Phenolic Network-Directed Coating ofFoods (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Manuel Pires-SantosCICECO - Aveiro Institute of Materials Department of Chemistry University of Aveiro Campus Universitário de Santiago 3810-193 Aveiro Portugal.ORCID https://orcid.org/0009-0002-2545-3236
Sara NadineCICECO - Aveiro Institute of Materials Department of Chemistry University of Aveiro Campus Universitário de Santiago 3810-193 Aveiro Portugal.ORCID https://orcid.org/0000-0001-5266-7657
João F ManoCICECO - Aveiro Institute of Materials Department of Chemistry University of Aveiro Campus Universitário de Santiago 3810-193 Aveiro Portugal.ORCID https://orcid.org/0000-0002-2342-3765

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The encapsulation of single cells has emerged as a promising field in recent years, owing to its potential applications in cell-based therapeutics, bioprinting, in vitro cell culture, high-throughput screening, and diagnostics. Single-cell units offer several advantages, including compatibility with standard imaging techniques, superior diffusion rates, and lower material-to-cell volume ratios. They also serve as effective carriers for targeted drug delivery, allowing precise administration of therapeutics in cell-mediated quantities. Moreover, single-cell units exhibit improved circulation potential throughout the vasculature, with a reduced likelihood of entrapment compared to multicell strategies. However, the production of single-cell units from random dispersion of cells follows the Poisson distribution, requiring the separation of empty and multicell units from single-cell ones. Various methods have been developed to address this challenge; nevertheless, the majority of these strategies are either expensive or time-consuming. This review provides an in-depth analysis of the advantages and limitations of single-cell units and their applications, as well as a comprehensive overview of the most used techniques for single-cell encapsulation and sorting strategies.

Indexed as

cell analysiscell therapymicrogelsPoisson distributionsingle‐cell encapsulationsorting strategies

Identifiers

PMID40213579
PMCPMC11935262

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.