Evidence map›Paper›PMID 40213571›Full record

ArticleSmall science2024

A Versatile Microchannel Array Device for Portable and Parallel Droplet Generation.

Zhengmin Tang, David Eun Reynolds, Caishu Lv, Dandan Zhang, Jina Ko, Yongcheng Wang

Abstract read
In one paragraph

Article in Small science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhengmin TangDepartment of Laboratory Medicine of The First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Hangzhou 311121 China.ORCID https://orcid.org/0000-0002-1096-4706
David Eun ReynoldsDepartment of Bioengineering Department of Pathology and Laboratory Medicine University of Pennsylvania Philadelphia 2926 USA.
Caishu LvDepartment of engineering Xinhaohui Biotech Hangzhou 311121 China.
Dandan ZhangDepartment of Pathology Key Laboratory of Disease Proteomics of Zhejiang Province School of Medicine Zhejiang University Hangzhou 310058 China.
Jina KoDepartment of Bioengineering Department of Pathology and Laboratory Medicine University of Pennsylvania Philadelphia 2926 USA.
Yongcheng WangDepartment of Laboratory Medicine of The First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Hangzhou 311121 China.ORCID https://orcid.org/0000-0003-2820-4243

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficient generation of monodispersed droplets holds great promise for micro-/nanoparticle synthesis and biochemical analysis. However, it remains a challenge to achieve high-throughput generation of monodispersed droplets in a portable and/or parallel manner in nonexpert biomedical laboratories. Herein, a versatile microchannel array (μCA) device is reported that is portable, multifaceted, reliable, and mass-manufacturable, supporting the high-throughput generation of monodispersed droplets in different ways. This device consists of a silicon-based μCA chip based on the step emulsification principle, as well as two matching plastic containers, both of which can be mass-manufactured by traditional microfabrication methods at low material costs. With the μCA device, aqueous solution can be dispersed into emulsion droplets by various modes, such as mechanical pump-based large-scale, handheld syringe-based portable, and gas pump-based highly parallel droplet generation. Furthermore, it is demonstrated that our cost-effective device can be applied for digital polymerase chain reaction analysis, supporting the need for more accessible microfluidic systems. Thus, the present device is expected to have a significant impact on both benchside and bedside applications.

Indexed as

digital polymerase chain reactionhigh‐throughput generationmicrofluidicsmonodispersed droplets

Identifiers

PMID40213571
PMCPMC11935260

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.