Evidence map›Paper›PMID 40213500›Full record

ArticleThe Lancet regional health. Europe2025

Maternal and neonatal outcomes of pregnancies after metabolic bariatric surgery: a retrospective population-based study.

Pierre Bel Lassen, Anne-Isabelle Tropeano, Armelle Arnoux, Estelle Lu, Louis Romengas, Sandrine Katsahian, Bérénice Ségrestin, Bénédicte Lelièvre, Delphine Mitanchez, Géraldine Gascoin and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet regional health. Europe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Weight management in women of reproductive age.Obesity and endocrinology · 2026
    Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Pierre Bel LassenUniversité Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), Paris F-75004, France.
Anne-Isabelle TropeanoAssistance Publique Hôpitaux de Paris, Unité de Recherche Clinique et Service de Santé Numérique, Université Paris Centre, Hôpital Européen Georges Pompidou, Paris F-75015, France.
Armelle ArnouxAssistance Publique Hôpitaux de Paris, Unité de Recherche Clinique et Service de Santé Numérique, Université Paris Centre, Hôpital Européen Georges Pompidou, Paris F-75015, France.
Estelle LuAssistance Publique Hôpitaux de Paris, Unité de Recherche Clinique et Service de Santé Numérique, Université Paris Centre, Hôpital Européen Georges Pompidou, Paris F-75015, France.
Louis RomengasAssistance Publique Hôpitaux de Paris, Unité de Recherche Clinique et Service de Santé Numérique, Université Paris Centre, Hôpital Européen Georges Pompidou, Paris F-75015, France.
Sandrine KatsahianAssistance Publique Hôpitaux de Paris, Unité de Recherche Clinique et Service de Santé Numérique, Université Paris Centre, Hôpital Européen Georges Pompidou, Paris F-75015, France.
Bérénice SégrestinCentre de Recherche en Nutrition Humaine Rhône-Alpes, Univ-Lyon, CarMeN Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Hospices Civils de Lyon, F-CRIN/FORCE Network, Pierre-Bénite, France.
Bénédicte LelièvreCHU Angers, Laboratoire de Pharmacologie-toxicologie, Angers F-49933, France.
Delphine MitanchezDepartment of Neonatology, Bretonneau Hospital, François Rabelais University, Tours F-37000, France.
Géraldine GascoinDepartment of Neonatal Medicine, Toulouse University Hospital Center, Toulouse, France.
Tigran PoghosyanAssistance Publique Hôpitaux de Paris, Service de Chirurgie Digestive, œsogastrique et Bariatrique, Hôpital Bichat, Université Paris Cité, Inserm UMRS 1149, Paris 75018, France.
Andrea LazzatiINSERM-INRIA-Université paris Cité, UMR 1346, HeKA Team, PariSanté Campus, Paris F-75015, France.
Barbara HeudeUniversité Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), Paris F-75004, France.
Jacky NizardAssistance Publique-Hôpitaux de Paris (AP-HP), Service de Gynécologie Obstétrique, Hôpital Pitié-Salpêtrière, Paris, France.
Sébastien CzernichowUniversité Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), Paris F-75004, France.
Cécile CianguraSorbonne University, Assistance Publique Hôpitaux de Paris, Service de Nutrition, Hôpital Pitié-Salpêtrière, Paris F-75013, France.
Claire Rives-LangeAssistance Publique Hôpitaux de Paris, Service de Nutrition, Hôpital Européen Georges Pompidou, Paris F-75015, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The incidence of post metabolic bariatric surgery (BS) pregnancies is rising. Previous studies provided conflicting results regarding the risk of prematurity, stillbirth, perinatal death and the optimal time from BS to conception. This study examined maternal and neonatal outcomes of post-BS pregnancies and influencing factors. Methods: Nationwide retrospective study of all post-BS pregnancies in France from January 1st 2013 to December 31st 2022. We compared 55,941 post-BS pregnancies with 223,712 controls matched on delivery date, parity, age, obesity, hypertension, diabetes, and socio-economic status (1:4 ratio) using generalized estimating equations. We also compared 11,777 post-BS pregnancies with 11,777 pre-BS pregnancies in the same women, using conditional logistic regression. Maternal outcomes included gestational hypertension, preeclampsia, and gestational diabetes. Neonatal outcomes included small-for-gestational-age (SGA), prematurity, stillbirth, and perinatal death. We tested for interactions with BS type, BS to pregnancy time interval and malnutrition. Findings: Post-BS pregnancies were associated with reduced risk of gestational hypertension (odds ratio [OR] 0.57 [95% CI 0.53-0.62]), preeclampsia (OR 0.59 [0.55-0.64]), and gestational diabetes (OR 0.64 [0.62-0.66]) as compared with control. Similar but stronger risk reductions were observed compared with pre-BS pregnancies. Risk of SGA was increased (OR 1.74 [1.68-1.79]) as compared with controls and pre-BS pregnancies (OR 1.88 [1.64-2.16]). Risk of prematurity was increased (OR 1.27 [1.22-1.31]) as compared with controls but not pre-BS pregnancies (OR 0.95 [0.85-1.06]). Compared with controls, risk of stillbirth was increased (OR 1.2 [1.06-1.35]), mediated by SGA, as was perinatal death (OR 1.5 [1.13-1.99]), mediated by both prematurity and SGA. Increased SGA risk compared to controls was higher with malnutrition (OR: 2.38 [1.96, 2.88], p Interpretation: Post-BS compared with pre-BS or control pregnancies were associated with reduced risk of maternal adverse outcomes but increased risk of neonatal adverse events. The risks of SGA and prematurity are higher with shorter intervals between BS and conception, gastric bypass, and malnutrition. Post-BS pregnancies could be considered high risk, requiring close nutritional and obstetrical monitoring. Funding: Support from INSERM and the French Ministry of Health (Messidore 2022 n°97).

Indexed as

Bariatric surgeryGastric bypassGestational diabetesGestational hypertensionMalnutritionNeonatal deathNutritionObesityPreeclampsiaPregnancyPrematuritySleeve gastrectomySmall-for-gestational age

Identifiers

PMID40213500
PMCPMC11982497

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.